C4284
β-Chloro-D-alanine hydrochloride
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关于此项目
线性分子式:
C3H6NO2Cl · HCl
化学文摘社编号:
分子量:
160.00
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
InChI key
IENJPSDBNBGIEL-HSHFZTNMSA-N
SMILES string
Cl.N[C@H](CCl)C(O)=O
InChI
1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m1./s1
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless
storage temp.
−20°C
Quality Level
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
J M Manning et al.
Proceedings of the National Academy of Sciences of the United States of America, 71(2), 417-421 (1974-02-01)
The D- and L-isomers of beta-chloroalanine inhibit the growth of Diplococcus pneumoniae, Streptococcus pyogenes, Bacillus subtilis, and Escherichia coli. With pneumococcus the inhibition by beta-chloro-D-alanine is completely prevented by either D-alanine or D-alanyl-D-alanine, while L-alanine is not effective in preventing
Jorge Cerbon et al.
Experimental parasitology, 122(2), 106-111 (2009-03-03)
The sphingolipids biosynthesis pathway generates bioactive molecules crucial to the regulation of physiological processes. We have recently reported that DAG (diacylglycerol) generated during sphingomyelin synthesis, plays an important role in PKC (protein kinase C) activation, necessary for the transit through
Yuki Ogasawara et al.
Journal of biochemical and biophysical methods, 51(2), 139-150 (2002-06-14)
A highly sensitive method has been developed for the determination of gamma-cystathionase (EC. 4.4.1.1.) activity in rat tissues using beta-chloro-L-alanine as a substrate. This method is based on colorimetry for the determination of pyruvate produced from beta-chloro-L-alanine with the beta-elimination
Arthur J L Cooper et al.
Biochemical pharmacology, 65(2), 181-192 (2002-12-31)
The mitochondrial and cytosolic branched-chain aminotransferases (BCAT(m) and BCAT(c)) are homodimers in the fold type IV class of pyridoxal 5'-phosphate-containing enzymes that also contains D-amino acid aminotransferase and 4-amino-4-deoxychorismate lyase (a beta-lyase). Recombinant human BCAT(m) and BCAT(c) were shown to
M Gupta et al.
Die Pharmazie, 59(3), 212-216 (2004-04-13)
The present study was designed to investigate the role of skin sphingosine inhibition in enhancing the transcutaneous permeation of 5-fluorouracil (5-FU), a hydrophilic drug, across rat skin. Ethanol-perturbation significantly reduced the sphingosine content as compared to that in normal skin
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