产品名称
胶原蛋白 来源于人类胎盘, Bornstein and Traub Type III (Sigma Type X), powder
生物来源
human placenta
质量水平
方案
≥90% (GE)
表单
powder
技术
cell culture | mammalian: suitable
杂质
HIV, hepatitis B and hepatitis C, none detected
溶解性
aqueous acid: soluble
UniProt登记号
储存温度
2-8°C
基因信息
human ... COL3A1(1300)
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应用
来自人胎盘的胶原蛋白已用于评估奎宁对气道上皮细胞的生物电效应、研究工程化慢病毒裂解肽的选择性毒性以及用于颗粒聚集测定以快速检测金黄色葡萄球菌（ Staphylococcus aureus）上的纤连蛋白、纤维蛋白原和胶原蛋白受体。 在表征人肺肿瘤相关抗原时，它还用于镁依赖型胶原蛋白结合试验。
制备说明
它是冻干粉，可以1 mg/mL溶于无菌的.5 M乙酸、PBS或水中。 PBS溶液在-20°C下至少可稳定保存一年。
分析说明
SDS聚丙烯酰胺凝胶电泳在和基底膜胶原蛋白相同的还原条件下测试，得到三条主要条带。
其他说明
所有胶原蛋白分子均由以三螺旋构象排列的三条肽链组成，其一级结构主要以三个氨基酸作为重复基序，即每隔两个氨基酸是一个甘氨酸残基，其前面的两个位置通常为脯氨酸或4-羟基脯氨酸。
胶原蛋白被分为许多种结构和遗传性不同的类型。 我们使用 Bornstein和Traub提出的系统命名法。 小心不要混淆Sigma命名系统和通用的胶原蛋白分类类型。
免责声明
该产品应在2-8 °C下保存，在此条件下活性可保持2年。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Johana Hrdinova et al.
International journal of molecular sciences, 23(4) (2022-02-27)
The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the role of
Chloe N Grover et al.
Journal of the mechanical behavior of biomedical materials, 10, 62-74 (2012-04-24)
Collagen-based scaffolds can be used to mimic the extracellular matrix (ECM) of soft tissues and provide support during tissue regeneration. To better match the native ECM composition and mechanical properties as well as tailor the degradation resistance and available cell
Sanne L N Brouns et al.
Research and practice in thrombosis and haemostasis, 6(2), e12678-e12678 (2022-03-15)
Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial) defect in protein C or S is explained by defective protein
Camila Martos Thomazini et al.
PLoS neglected tropical diseases, 15(9), e0009715-e0009715 (2021-09-04)
Patients bitten by snakes consistently manifest a bleeding tendency, in which thrombocytopenia, consumption coagulopathy, mucous bleeding, and, more rarely, thrombotic microangiopathy, are observed. Von Willebrand factor (VWF) is required for primary hemostasis, and some venom proteins, such as botrocetin (a
Natalie J Jooss et al.
International journal of molecular sciences, 20(11) (2019-06-12)
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by integrin α2β1. Protein tyrosine kinase Syk is central in the GPVI-induced
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