一般描述
含腺嘌呤的柠檬酸盐-磷酸盐-葡萄糖溶液 (CPDA) 是一种用于储存血液的抗凝剂和防腐剂。可将红细胞保存期限延长至 35 天。维持血小板活性。使用 CPDA 可提高输血后可视性，改善血液中的葡萄糖和 ATP 水平。
应用
含腺嘌呤的柠檬酸盐-磷酸盐-葡萄糖溶液已被用作心脏穿刺采血过程中的抗凝剂， 转基因鸡蛋溶菌酶-卵清蛋白-Duffy (HOD) 小鼠 和人类。
生化/生理作用
可用于全血的抗凝
建议的抗凝血剂:全血比为 1:9
建议的抗凝血剂:全血比为 1:9
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Krishnan MohanKumar et al.
Nature communications, 10(1), 3494-3494 (2019-08-04)
Necrotizing enterocolitis (NEC) is an idiopathic, inflammatory bowel necrosis of premature infants. Clinical studies have linked NEC with antecedent red blood cell (RBC) transfusions, but the underlying mechanisms are unclear. Here we report a neonatal murine model to investigate this
HyunJoo Park et al.
Scientific reports, 6, 34257-34257 (2016-10-05)
The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusions. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were quantified in blood samples stored for various
James C Keith et al.
Arthritis research & therapy, 7(4), R769-R776 (2005-07-01)
The human leukocyte antigen B27 (HLA-B27) transgenic rat is a model of human inflammatory bowel disease, rheumatoid arthritis and psoriasis. Studies of chronic inflammation in other rat models have demonstrated activation of the kallikrein-kinin system as well as modulation by
A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat
Keith JC, et al.
Arthritis Research & Therapy, 7(4), R769-R769 (2005)
Measuring cell surface area and deformability of individual human red blood cells over blood storage using quantitative phase imaging
Park H, et al.
Scientific reports, 6(6), 34257-34257 (2016)
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