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文件

C4522

西咪替丁

Name: 西咪替丁
Brand: SIGMA

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别名:

SKF-92334

经验公式（希尔记法）:

C₁₀H₁₆N₆S

CAS号:

51481-61-9

分子量:

252.34

EC 号:

257-232-2

MDL编号:

MFCD00133296

PubChem化学物质编号:

24277766

NACRES:

NA.77

形式

powder

质量水平

200

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES string

CN\C(NC#N)=N\CCSCc1nc[nH]c1C

InChI

1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

InChI key

AQIXAKUUQRKLND-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243) , CYP1A2(1544) , CYP3A4(1576) , HRH2(3274) , SLC9A2(6549) , SLC9A5(6553)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Slc9a1(24782) , Slc9a3(24784) , Slc9a5(192215)

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生化/生理作用

H₂组胺受体拮抗剂；I₁咪唑啉受体激动剂；抗溃疡剂。通过抑制内皮细胞表面上E-选择蛋白的表达来阻断癌症转移，从而阻断肿瘤细胞的粘附。

特点和优势

该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.

K Kobayashi et al.

Cancer research, 60(14), 3978-3984 (2000-08-05)

Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated. In this report, we have demonstrated for the first time that cimetidine

Selective ligands as tools to study histamine receptors.

H van der Goot et al.

European journal of medicinal chemistry, 35(1), 5-20 (2000-03-25)

In this review the histaminergic ligands for the histamine H(1), H(2) and H(3) receptors, which are currently used as tools in pharmacological studies, are described. To study interactions with the histamine H(1) receptor, the H(1) agonist 2-aminoethylthiazole has long since

Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells.

Sarit Pal et al.

Biology open, 11(7) (2022-07-02)

Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and tissue types.

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.

Huan Yang et al.

Molecular medicine (Cambridge, Mass.), 28(1), 57-57 (2022-05-17)

Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical

Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen-Bond-Accepting Amino Acid Side Chains.

Hiroki Shimizu et al.

ChemMedChem, 17(16), e202200204-e202200204 (2022-06-14)

We synthesized and experimentally tested the passive permeability of more than thirty tetrapeptides mimicking the N-terminus of the pro-apoptotic protein Smac (Second mitochondria-derived activator of caspases). Each peptide bore one or two unnatural Hydrogen Bond Acceptor-bearing Amino Acid (HBA-AA) residues

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