C4615
Cloricromene
≥98% (HPLC), solid
别名:
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6
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关于此项目
经验公式（希尔记法）:
C20H26ClNO5 · HCl
化学文摘社编号:
分子量:
432.34
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
solid
颜色
white
mp
221-222.3 °C
溶解性
DMSO: 17 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl
InChI
1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
InChI key
CCCZJRFQJNGCCU-UHFFFAOYSA-N
生化/生理作用
Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation.
Liquefying Compounds by Forming Deep Eutectic Solvents: A Case Study for Organic Acids and Alcohols.
Dinis O Abranches et al.
The journal of physical chemistry. B, 124(20), 4174-4184 (2020-04-24)
The criterion to distinguish a simple eutectic mixture from a deep eutectic solvent (DES) lies in the deviations to thermodynamic ideality presented by the components in the system. In this work, the current knowledge of the molecular interactions in types
D Altavilla et al.
The American journal of physiology, 268(4 Pt 2), H1412-H1417 (1995-04-01)
Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase
G Calapai et al.
Naunyn-Schmiedeberg's archives of pharmacology, 351(2), 209-215 (1995-02-01)
The effects of different doses (0.25, 0.5, 1 and 2 mg/kg i.p.) of cloricromene, a coumarine derivative, have been investigated on brain malondialdehyde levels, brain edema, myeloperoxidase activity, survival, locomotor hyperactivity and hippocampal neuronal loss following transient cerebral ischemia induced
E Ribaldi et al.
British journal of pharmacology, 118(6), 1351-1358 (1996-07-01)
1. A phospholipase A2 (PLA2) represents the key enzyme in the remodelling pathway of platelet-activating factor (PAF) synthesis in human polymorphonuclear (PMN) leucocytes. 2. PLA2 activation is also the rate-limiting step for the release of the arachidonic acid utilized for
R Pignatello et al.
The Journal of pharmacy and pharmacology, 58(7), 1001-1005 (2006-06-30)
The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but
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