C4615
Cloricromene
≥98% (HPLC), solid
别名:
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6
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关于此项目
经验公式（希尔记法）:
C20H26ClNO5 · HCl
化学文摘社编号:
分子量:
432.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
InChI key
CCCZJRFQJNGCCU-UHFFFAOYSA-N
SMILES string
Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl
InChI
1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
assay
≥98% (HPLC)
form
solid
color
white
mp
221-222.3 °C
solubility
DMSO: 17 mg/mL, H2O: insoluble
storage temp.
2-8°C
Biochem/physiol Actions
Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation.
L Groban et al.
Clinical and experimental pharmacology & physiology, 25(6), 417-423 (1998-07-23)
1. The aim of the present investigation was to evaluate the effect of cloricromene on myocardial infarct size, regional myocardial blood flow and neutrophil accumulation in a canine model of ischaemia-reperfusion. 2. Dogs were instrumented to measure blood pressure, left
R Pignatello et al.
The Journal of pharmacy and pharmacology, 58(7), 1001-1005 (2006-06-30)
The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but
F Squadrito et al.
British journal of pharmacology, 113(4), 1153-1158 (1994-12-01)
1. Splanchnic artery occlusion (SAO) shock is characterized by irreversible circulatory failure. Tumour necrosis factor (TNF-alpha) may affect the L-arginine/nitric oxide (NO) pathway, thus contributing to the cardiovascular derangements of circulatory shock. 2. We investigated the contribution of both TNF-alpha
D A Zvara et al.
Anesthesia and analgesia, 84(2), 266-270 (1997-02-01)
Cloricromene is a coumarin derivative without anticoagulant activities that has recently been found to decrease myocardial infarct size after an ischemic-reperfusion injury. This study seeks to determine when the cardioprotective action of cloricromene is exerted in an in vivo rabbit
Claudio Bucolo et al.
Investigative ophthalmology & visual science, 50(8), 3846-3852 (2009-03-13)
Retinal microvascular cells play a crucial role in the pathogenesis of diabetic retinopathy. The endothelial effects of cloricromene, a novel coumarin derivative, on diabetic retinopathy induced by streptozotocin (STZ) in the rat were investigated. Cloricromene (10 mg/kg intraperitoneally) was administered
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