产品名称
羧基酯酶2 人, recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
specific activity
≥1.0 EU/μg
30,000 pmol/min-μg protein
recombinant
expressed in mouse NSO cells
assay
≥95% (SDS-PAGE)
form
solution
mol wt
predicted mol wt ~60 kDa
concentration
0.4-0.6 mg/mL
impurities
≤1.0 EU/μg endotoxin
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... CES2(8824)
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Biochem/physiol Actions
人羧酸酯酶2（hCE-2）可识别具有大醇基和小酰基的底物。由于在活性位点口袋中存在构象干扰，其底物特异性可能受到酰基-hCE-2缀合物形成能力的限制。羧基酯酶可催化几种含酯的药物和前药的生物转化，例如血管紧张素转化酶抑制剂（替莫卡普、西拉普利）、抗肿瘤药（卡培他滨）和麻醉药。
可水解酯和酰胺键的丝氨酸酯酶家族成员。羧基酯酶2是一种内质网结合的水解酶，在异源生物解毒和活化含酯治疗剂中起关键作用。羧基酯酶2也可参与海洛因和可卡因等药物的解毒过程。该酶被认为在脂质代谢中起作用。
Other Notes
一个酶活性单位是指在pH 7.5、25 °C下，每分钟水解1pmol对硝基苯乙酸酯所需的酶量。
Physical form
以含有氯化钠、乙酸钠和20％甘油的溶液形式提供。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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