C4859
环己酰亚胺 溶液
Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture
别名:
CHX
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关于此项目
经验公式（希尔记法）:
C15H23NO4
化学文摘社编号:
分子量:
281.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
SMILES string
O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
biological source
microbial
description
suitable for testing specifications (CHO C. growth inhibitor)
form
ready-to-use solution
concentration
100 mg/mL in DMSO
solubility
DMSO: soluble
antibiotic activity spectrum
fungi, yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Gene Information
human ... FKBP1A(2280), PIN1(5300)
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Application
Cycloheximide solution has been used:
- to study its role in modulating cell death induced by tumor necrosis factor α (TNFα) in combination with the second mitochondria-derived activator of caspases (SMAC) mimetic birinapant or interferon-gamma (IFNγ), specifically under conditions that inhibit caspase-8 activity
- in the study to inhibit protein translation during the CHX-chase assays
- to treat antisense oligonucleotide (AON) transfected patient-derived fibroblasts and inhibit the nonsense-mediated decay (NMD) pathway to analyze the therapeutic potential AON and visualize the transcript containing the pseudoexon (PE)
Biochem/physiol Actions
环己酰亚胺（CHX）是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。
经测试可用于细胞生长停滞、选择抗环己酰亚胺的酵母、诱导凋亡、以及促进通过FasL凋亡的诱导。
Other Notes
保存于密闭容器内，置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。储存类别（TRGS 510）：不可燃，急性毒性，1和2类/剧毒有害物质。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
法规信息
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