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Merck
CN

C4859

环己酰亚胺 溶液

Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

别名:

CHX

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关于此项目

经验公式（希尔记法）:
C15H23NO4
化学文摘社编号:
66-81-9
分子量:
281.35
NACRES:
NA.77
PubChem Substance ID:
24892732
UNSPSC Code:
12352111
MDL number:
MFCD00082346

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产品名称

环己酰亚胺 溶液, Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

SMILES string

O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

biological source

microbial

description

suitable for testing specifications (CHO C. growth inhibitor)

form

ready-to-use solution

concentration

100 mg/mL in DMSO

solubility

DMSO: soluble

antibiotic activity spectrum

fungi
yeast

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... FKBP1A(2280), PIN1(5300)

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相关类别

Biochem/physiol Actions

环己酰亚胺（CHX）是由灰链霉菌产生的一种抗生素。它的主要生物学活性是真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。
经测试可用于细胞生长停滞、选择抗环己酰亚胺的酵母、诱导凋亡、以及促进通过FasL凋亡的诱导。

Other Notes

保存于密闭容器内，置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。储存类别（TRGS 510）：不可燃，急性毒性，1和2类/剧毒有害物质。

Application

Cycloheximide solution has been used:
  • to study its role in modulating cell death induced by tumor necrosis factor α (TNFα) in combination with the second mitochondria-derived activator of caspases (SMAC) mimetic birinapant or interferon-gamma (IFNγ), specifically under conditions that inhibit caspase-8 activity
  • in the study to inhibit protein translation during the CHX-chase assays
  • to treat antisense oligonucleotide (AON) transfected patient-derived fibroblasts and inhibit the nonsense-mediated decay (NMD) pathway to analyze the therapeutic potential AON and visualize the transcript containing the pseudoexon (PE)

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

法规信息

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分析证书(COA)

Lot/Batch Number
0000486680
0000486680
0000471003
0000471003
0000431728

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