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C4911

氯噻嗪

Name: 氯噻嗪
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder

别名:

6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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关于此项目

经验公式（希尔记法）:

C₇H₆ClN₃O₄S₂

化学文摘社编号:

58-94-6

分子量:

295.72

NACRES:

NA.77

PubChem Substance ID:

24278150

UNSPSC Code:

12352202

EC Number:

200-404-9

MDL number:

MFCD00058576

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属性

产品名称

氯噻嗪, thiazide diuretic

biological source

synthetic (organic)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

mp

>300 °C

solubility

DMF: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

2-8°C

SMILES string

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChI key

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA4(762), SLC12A3(6559)

说明

General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.

One of the first in the thiazide class of diuretics.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

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象形图

GHS08

警示词

Danger

危险代码

H317,H334

预防性声明

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

怎么回事？

WGK 2

闪点 (F)

Not applicable

闪点 (°C)