C4911
氯噻嗪
synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder
别名:
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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关于此项目
经验公式（希尔记法）:
C7H6ClN3O4S2
化学文摘社编号:
分子量:
295.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-404-9
MDL number:
产品名称
氯噻嗪, thiazide diuretic
biological source
synthetic (organic)
Quality Segment
assay
≥98% (HPLC)
form
powder
mp
>300 °C
solubility
DMF: 50 mg/mL, clear, colorless to very faintly yellow
storage temp.
2-8°C
SMILES string
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
Gene Information
human ... CA1(759), CA4(762), SLC12A3(6559)
General description
Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.
Application
Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.
One of the first in the thiazide class of diuretics.
Biochem/physiol Actions
Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.
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signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves