biological source
Xanthium sibiricum
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D -34 to -48°, c = 0.5 in water
storage condition
desiccated
color
white
solubility
H2O: ≥10 mg/mL
storage temp.
−20°C
Application
羧基苍术苷钾盐已被用作Ca 2+诱导的mPTP(1-甲基-4-苯基-1,2,3,6-四氢吡啶) 开环的激活剂 。它还已被用作腺嘌呤核苷酸转运蛋白(ANT)抑制剂，以研究抑制完整T98G神经胶质瘤细胞中的氧化磷酸化的抑制作用。
Biochem/physiol Actions
羧基苍术苷是细胞溶质侧特异性线粒体ADP/ATP载体的高选择性抑制剂；即腺嘌呤核苷酸转位酶（ANT）；使ANT的c构象稳定，导致渗透性转换孔（PTP）开放、线粒体膜电位丧失和细胞凋亡。
Features and Benefits
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctions
Jiang H, et al.
Journal of Neurochemistry, 140(2), 307-319 (2017)
Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells
Ruas J S, et al.
PLoS ONE, 11(3), e0150967-e0150967 (2016)
Juliana S Ruas et al.
PloS one, 11(3), e0150967-e0150967 (2016-03-08)
The maximal capacity of the mitochondrial electron transport system (ETS) in intact cells is frequently estimated by promoting protonophore-induced maximal oxygen consumption preceded by inhibition of oxidative phosphorylation by oligomycin. In the present study, human glioma (T98G and U-87MG) and
Chen Zhang et al.
Scientific reports, 7, 44708-44708 (2017-03-21)
Mitochondria are intracellular organelles involved in cell survival and death, and dysfunctions of mitochondria are related to neurodegenerative diseases. As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial
N Senoo et al.
Science advances, 6(35), eabb0780-eabb0780 (2020-09-15)
The phospholipid cardiolipin has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports the structure and function of proteins and protein complexes are poorly understood. To address this
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Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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