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Merck
CN

C5020

头孢唑啉 钠盐

89.1-110.1%

别名:

Cefazoline sodium, Monosodium cefazolin

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关于此项目

经验公式(希尔记法):
C14H13N8NaO4S3
化学文摘社编号:
分子量:
476.49
UNSPSC Code:
51282532
NACRES:
NA.76
PubChem Substance ID:
EC Number:
248-278-4
Beilstein/REAXYS Number:
3585038
MDL number:
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产品名称

头孢唑啉 钠盐, 89.1-110.1%

InChI key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

InChI

1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

SMILES string

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C([O-])=O)s1

assay

89.1-110.1%

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

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Biochem/physiol Actions

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins, especially PBP2 and PBP4 on bacterial cell wall mucopeptide synthesis.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Preparation Note

Freely soluble in water, very slightly soluble in chloroform and ethanol.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tim Garrett et al.
Emergency medicine Australasia : EMA, 24(4), 383-392 (2012-08-07)
Cellulitis is a common presentation to the ED and a significant cause of hospitalization that can be managed in hospital-in-the-home programmes. Current clinical-practice guidelines recommend once or twice-daily i.v. antibiotics; however, there is an absence of data describing the impact
Francesca D'Este et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 777-789 (2017-07-15)
The prevention of implant-associated infection, one the most feared complications in orthopaedic surgery, remains a major clinical challenge and urges development of effective methods to prevent bacterial colonization of implanted devices. Alpha-helical antimicrobial peptides (AMPs) may be promising candidates in
Mei Zhang et al.
Therapeutic drug monitoring, 40(6), 682-692 (2018-07-18)
Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, and reliable analytical method for monitoring the concentrations in plasma, including unbound concentrations for highly protein-bound drugs. The aim of the current work was to develop and validate
Bo-Bae Seo et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 106(2), 751-759 (2017-03-24)
An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created
Colleen K Cagno et al.
American family physician, 86(1), 59-65 (2012-09-12)
Group B streptococcus is the leading cause of early-onset neonatal sepsis in the United States. Universal screening is recommended for pregnant women at 35 to 37 weeks' gestation. The Centers for Disease Control and Prevention recently updated its guideline for

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