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Merck
CN

C5020

头孢唑啉 钠盐

89.1-110.1%

别名:

Cefazoline sodium, Monosodium cefazolin

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关于此项目

经验公式(希尔记法):
C14H13N8NaO4S3
化学文摘社编号:
分子量:
476.49
UNSPSC Code:
51282532
NACRES:
NA.76
PubChem Substance ID:
EC Number:
248-278-4
Beilstein/REAXYS Number:
3585038
MDL number:
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产品名称

头孢唑啉 钠盐, 89.1-110.1%

InChI key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

InChI

1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

SMILES string

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C([O-])=O)s1

assay

89.1-110.1%

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

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Biochem/physiol Actions

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins, especially PBP2 and PBP4 on bacterial cell wall mucopeptide synthesis.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Preparation Note

Freely soluble in water, very slightly soluble in chloroform and ethanol.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Francesca D'Este et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 777-789 (2017-07-15)
The prevention of implant-associated infection, one the most feared complications in orthopaedic surgery, remains a major clinical challenge and urges development of effective methods to prevent bacterial colonization of implanted devices. Alpha-helical antimicrobial peptides (AMPs) may be promising candidates in
Mei Zhang et al.
Therapeutic drug monitoring, 40(6), 682-692 (2018-07-18)
Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, and reliable analytical method for monitoring the concentrations in plasma, including unbound concentrations for highly protein-bound drugs. The aim of the current work was to develop and validate
Bo-Bae Seo et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 106(2), 751-759 (2017-03-24)
An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created
Tim Garrett et al.
Emergency medicine Australasia : EMA, 24(4), 383-392 (2012-08-07)
Cellulitis is a common presentation to the ED and a significant cause of hospitalization that can be managed in hospital-in-the-home programmes. Current clinical-practice guidelines recommend once or twice-daily i.v. antibiotics; however, there is an absence of data describing the impact
Martin Andreas et al.
The Annals of thoracic surgery, 95(4), 1323-1329 (2013-03-07)
Internal mammary artery (IMA) harvesting for coronary artery bypass grafting (CABG) influences tissue perfusion and represents a risk factor for deep sternal wound infection (DSWI). Cephalosporins are routinely administered for prophylaxis during cardiac operations to decrease perioperative wound infections. We

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