C5145
Chlormadinone acetate
≥98%
别名:
17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione, 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate, 6-Chloro-6-dehydro-17α-acetoxyprogesterone, Gestafortin, Matrol, Menstridyl
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关于此项目
经验公式（希尔记法）:
C23H29ClO4
化学文摘社编号:
分子量:
404.93
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-118-0
Beilstein/REAXYS Number:
2633614
MDL number:
产品名称
Chlormadinone acetate, ≥98%
InChI key
QMBJSIBWORFWQT-DFXBJWIESA-N
InChI
1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1
SMILES string
[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(Cl)C4=CC(=O)CC[C@]24C
assay
≥98%
form
powder
Quality Level
Gene Information
human ... PGR(5241)
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Biochem/physiol Actions
Review of progestogenic and related pharmacological effects of chlormadinone acetate.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Gunther Göretzlehner et al.
Clinical drug investigation, 31(4), 269-277 (2011-01-22)
The prescribing of extended regimens of oral contraceptives (OCs) is increasing in routine gynaecological practice as a means of reducing the number of annual menstrual bleeds. Typically, this involves taking one pill per day for, say, 84 days continuously (4×21
Nathalie Chabbert-Buffet et al.
Contraception, 83(3), 229-237 (2011-02-12)
Systemic lupus erythematosus (SLE) affects women of child-bearing age. Combined oral contraceptives can worsen the course and increase the risk of thrombosis. The objectives of this study were to provide an alternative contraception and thus evaluate the gynecological tolerability of
Maurizio Guido et al.
Reproductive sciences (Thousand Oaks, Calif.), 17(8), 767-775 (2010-07-03)
This is the first study evaluating the clinical, metabolic, and hormonal effects of the ethinylestradiol-chlormadinone acetate (EECMA) combination in hirsute women with polycystic ovary syndrome (PCOS). Ultrasonographic pelvic examination, hirsutism score, and hormone profile evaluation were performed at baseline and
Ting Huang et al.
Die Pharmazie, 66(3), 212-215 (2011-05-11)
Chlormadinone acetate (CMA), a derivative of 17-a-hydroxyprogesterone, has been widely used as an orally effective progestogen in hormone replacement therapy (HRT). Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the major steps responsible for the metabolism of many drugs, environmental
R Hermes et al.
Theriogenology, 78(6), 1217-1223 (2012-08-18)
The estrous cycle length in the white rhinoceros (Ceratotherium simum) is either 4 or 10 wk. The cause(s) for this variation as well as the poor fertility rate in captivity remains under debate in this species. Most captive adult white
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