C5147
β-Casomorphin Fragment 1-5 hydrochloride
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C30H37N5O7
化学文摘社编号:
分子量:
579.64
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
β-Casomorphin Fragment 1-5 hydrochloride, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
solid
储存温度
−20°C
SMILES字符串
NC(Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NC(Cc3ccccc3)C(=O)N4CCCC4C(=O)NCC(O)=O
InChI
1S/C30H37N5O7/c31-22(16-20-10-12-21(36)13-11-20)29(41)34-14-5-9-25(34)28(40)33-23(17-19-6-2-1-3-7-19)30(42)35-15-4-8-24(35)27(39)32-18-26(37)38/h1-3,6-7,10-13,22-25,36H,4-5,8-9,14-18,31H2,(H,32,39)(H,33,40)(H,37,38)
InChI key
PKKIDZFGRQACGB-UHFFFAOYSA-N
Amino Acid Sequence
Tyr-Pro-Phe-Pro-Gly
生化/生理作用
β-Casomorphin Fragment 1-5 (BCM5), an opioid receptor agonist, is a member of the β-casomorphin peptide family derived from β-casein. β-casomorphins are used to study their differential effects on processes such as hyperglycemia, oxidative stress, opioid signalling and immunosuppression.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
[Affect of peptide and non-peptide opioids on the defensive reaction of the cockroach Periplaneta americana in the "hot chamber"].
O B Gritsaĭ et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 40(2), 125-130 (2004-07-29)
Minoru Sakaguchi et al.
European journal of pharmacology, 530(1-2), 81-87 (2005-12-20)
The effects of systemic administration of bovine beta-casomorphin-5 (Tyr-Pro-Phe-Pro-Gly), a mu-opioid receptor agonist derived from milk beta-casein, on spontaneous alternation behavior in the Y-maze (spatial short-term memory) and step-down-type passive avoidance response (non-spatial long-term memory) were investigated in mice. Intraperitoneal
Effects of beta-casomorphin on 3H-ouabain binding to guinea pig heart membranes.
C Liebmann et al.
Die Pharmazie, 41(9), 670-671 (1986-09-01)
K A Carpenter et al.
International journal of peptide and protein research, 48(1), 102-111 (1996-07-01)
The conformational properties of three cyclic beta-casomorphin analogs based on the general formula H-Tyr-c[-D-Orn-2-Nal-D-Pro-Xaa-] (2-Nal = 2-naphthylalanine; Xaa = D-Ala, Sar or NMe-Ala) in DMSO solution were investigated using NMR spectroscopy in conjunction with molecular modeling techniques. The D-Ala5- and
N G Delaet et al.
Biopolymers, 32(8), 957-969 (1992-08-01)
In order to prevent enzymatic degradation of beta-casomorphin-5 (1) and morphiceptin, reduced peptide bonds were incorporated at the 2-3 and 3-4 bonds, respectively. The analogues were synthesized by a combination of solid phase methodology and reductive alkylation of resin-bound peptide
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