C5174
4′-氯地西泮
≥98% (TLC)
别名:
7-氯-5-（4-氯苯基）-1,3-二氢-1-甲基-2H-1,4-苯二氮卓-2-酮, Ro 5-4864, Ro5-4864
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关于此项目
经验公式（希尔记法）:
C16H12Cl2N2O
CAS Number:
分子量:
319.19
Beilstein:
685202
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (TLC)
表单
powder
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
溶解性
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
SMILES字符串
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
InChI
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
InChI key
PUMYFTJOWAJIKF-UHFFFAOYSA-N
基因信息
rat ... Tspo(24230)
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应用
4′-氯地西泮在线粒体功能研究中用作转运蛋白配体。此外，也用于研究其对葡萄糖缺失T98G星形胶质细胞的保护作用。
生化/生理作用
4'-氯二氮卓酮 (Ro5-4864) 是线粒体转运蛋白 18 kDa (TSPO) 的强效选择性配体，以前称为外周苯二氮卓类受体 (PBR)。Ro5-4864 不与 GABA (A) 受体结合，缺乏典型的苯二氮卓类效应，但在多项研究中发现其具有神经保护作用。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats
Musman J, et al.
Biochemical Pharmacology, 142, 87-95 (2017)
4?-Chlorodiazepam protects mitochondria in T98G astrocyte cell line from glucose deprivation
Baez E, et al.
Neurotoxicity Research, 32(2), 163-171 (2017)
Federico Da Settimo et al.
Journal of medicinal chemistry, 51(18), 5798-5806 (2008-08-30)
Novel N,N-disubstituted indol-3-ylglyoxylamides (1-56), bearing different combinations of substituents R 1-R 5, were synthesized and evaluated as ligands of the translocator protein (TSPO), the 18 kDa protein representing the minimal functional unit of the "peripheral-type benzodiazepine receptor" (PBR). Most of
S Giatti et al.
Neuroscience, 164(2), 520-529 (2009-08-12)
Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of
Lauren H Fairley et al.
Journal of neuroinflammation, 18(1), 76-76 (2021-03-21)
The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer's disease (AD). While TSPO ligands have been shown to reduce the accumulation of the toxic
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