C5259
Carbamyl-β-methylcholine chloride
≥99% (TLC), crystalline
别名:
Bethanechol chloride
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关于此项目
线性分子式:
C7H17N2O2Cl
化学文摘社编号:
分子量:
196.68
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
209-686-8
MDL number:
产品名称
Carbamyl-β-methylcholine chloride, ≥99% (TLC), crystalline
InChI key
AIRHOJQHGLTTTB-UHFFFAOYSA-N
InChI
1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H
SMILES string
Cl.CC(C[N](C)(C)C)OC(N)=O
assay
≥99% (TLC)
form
crystalline
color
white
solubility
H2O: 1.7 g/mL (stable for several days at 4°C.)
ethanol: 80 mg/mL (stable for several days at 4°C.)
storage temp.
2-8°C
Quality Level
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Disclaimer
Hygroscopic.
General description
Muscarinic acetylcholine receptor agonist that is not a substrate for acetylcholinesterase.
Application
Carbamyl-β-methylcholine chloride has been used in western blotting and bactericidal assay. It has also been used in concentration-response studies with isolated atrial preparation.
Biochem/physiol Actions
Carbamyl-β-methylcholine has a selective action on urinary bladder and intestine. It induces smooth muscle tension in the bladder. Its main function is to induce detrusor muscle action, mediated by postganglionic parasympathetic effector cells. Nausea, flushing, sweating, abdominal cramps are some of the side effect caused by carbamyl-β-methylcholine.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Time course of isolated rat fundus response to muscarinic agonists: a measure of intrinsic efficacy.
S M Jankovic et al.
Physiological research, 47(6), 463-470 (1999-08-24)
The establishment of a dose-response relationship and its quantification is the usual procedure for analysing drug action on an isolated organ. However, the time course of the effect seems to be an inherent characteristic of the agonist which produces it.
Darryl J Adamko et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 14(5), 321-327 (2012-05-23)
Diagnosing asthma in infancy is largely made on the basis of the symptoms of cough and wheezing. A similar presentation can be seen in neurologically normal infants with excessive gastroesophageal reflux (GER). There are no randomized placebo controlled studies in
Penn Clinical Manual of Urology, 454-454 (2014)
Remodeling of cardiac cholinergic innervation and control of heart rate in mice with streptozotocin-induced diabetes
Mabe AM and Hoover DB
Autonomic Neuroscience : Basic & Clinical, 162(1-2), 24-31 (2011)
Pharmacology for the Primary Care Provider, 380-380 (2008)
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