C5438
8-（4-氯苯硫基）-鸟苷 3′,5′-环单磷酸 钠盐
≥95% (HPLC), cGMP dependent protein kinase (PKG) activator, powder
别名:
8-pCPT-cGMP, pCPT-cGMP
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关于此项目
经验公式（希尔记法）:
C16H14ClN5NaO7PS
化学文摘社编号:
分子量:
509.79
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
产品名称
8-（4-氯苯硫基）-鸟苷 3′,5′-环单磷酸 钠盐, ≥95% (HPLC), powder
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white
溶解性
H2O: 25 mg/mL
储存温度
−20°C
SMILES字符串
[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1
InChI
1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
InChI key
REEQGIQRCDWDRA-ZBMQJGODSA-M
相关类别
应用
8-（4-氯苯硫基）-鸟苷 3′,5‘-环状单磷酸钠盐已被用于激活血管平滑肌细胞（VSMC）中的GMP依赖性蛋白激酶（PKG）。
生化/生理作用
cGMP的膜渗透性类似物，不影响cGMP调节的磷酸二酯酶。 比8-Br-cGMP更有效的cGMP类似物，因为它具有更高的膜渗透性和更高的抗磷酸二酯酶水解能力。用作cGMP依赖性蛋白激酶（PKG）的选择性激活剂。被发现是一种非常有效的环状核苷酸门控通道激动剂。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yang Chen et al.
Circulation research, 124(10), 1462-1472 (2019-04-02)
Acute kidney injury (AKI) has a high prevalence and mortality in critically ill patients. It is also a powerful risk factor for heart failure incidence driven by hemodynamic changes and neurohormonal activation. However, no drugs have been approved by the
P He et al.
The American journal of physiology, 274(6 Pt 2), H1865-H1874 (1998-06-25)
To investigate the mechanisms whereby guanosine 3',5'-cyclic monophosphate (cGMP) modulates microvessel permeability in vivo, we measured changes in microvessel hydraulic conductivity (Lp) and endothelial cytoplasmic Ca2+ concentration ([Ca2+]i) in response to the cGMP analogs 8-bromo-cGMP (8-BrcGMP) and 8-(p-chlorophenylthio)cGMP (8-pCPT-cGMP) in
M Suhasini et al.
Molecular and cellular biology, 18(12), 6983-6994 (1998-11-20)
Agents which increase the intracellular cyclic GMP (cGMP) concentration and cGMP analogs inhibit cell growth in several different cell types, but it is not known which of the intracellular target proteins of cGMP is (are) responsible for the growth-suppressive effects
Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries.
Richard B Thorpe et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R734-R743 (2013-03-01)
Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G (PKG) mediates many effects of soluble guanylate cyclase activation through phosphorylation of multiple kinase targets in vascular smooth muscle, we tested the hypothesis
B E VanUffelen et al.
Biochemical pharmacology, 56(8), 1061-1063 (1998-10-17)
In previous experiments, it was shown that migration of electropermeabilized human neutrophils induced by a combination of cGMP and cAMP markedly lower relative to that induced by cGMP or cAMP alone. However, when cGMP was replaced with 8-(para-chlorophenylthio-guanosine-3',5'-cyclic monophosphate (8-pCPT-cGMP)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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