C5490
C75
≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder
别名:
4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸
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关于此项目
经验公式（希尔记法）:
C14H22O4
CAS Number:
分子量:
254.32
MDL编号:
UNSPSC代码:
41121801
PubChem化学物质编号:
NACRES:
NA.77
Product Name
C75, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
InChI key
VCWLZDVWHQVAJU-UHFFFAOYSA-N
相关类别
应用
C75用于：
- 作为脂肪酸合酶（FASN）抑制剂，测试其相较于二甲双胍，对FASN的直接抑制作用以及减弱乳腺球形成的能力
- 作为抑制神经胶质瘤干细胞（GSC）中脂肪酸合成的药理抑制剂
- 作为FAS 抑制剂 对Chang细胞进行预处理，以抑制脂肪生成并逆转过氧化氢诱导的衰老
生化/生理作用
C75是一种新型、有效的脂肪酸合成酶（FAS）合成抑制剂，可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
C75有助于提高电离辐射的抗癌能力。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
Kim YM, et al.
Test, 285(38), 29069-29077 (2010)
Yuta Sakae et al.
Biology open, 9(4) (2020-04-09)
The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal.
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b
Wahdan-Alaswad RS, et al.
Hormones & Cancer, 5(6), 374-389 (2014)
Song-Hyo Jin et al.
PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Rae C, et al.
Chirality, 29(1), 10-13 (2017)
商品
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Discover Bioactive Small Molecules for Lipid Signaling Research
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