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Merck
CN

C5776

可卡因标准液 盐酸盐

CNS stimulator, powder

别名:

苯甲酰甲基芽子碱 盐酸盐

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关于此项目

经验公式（希尔记法）:
C17H21NO4 · HCl
化学文摘社编号:
53-21-4
分子量:
339.81
NACRES:
NA.77
PubChem Substance ID:
329775099
UNSPSC Code:
12352200
EC Number:
200-167-1
MDL number:
MFCD00058119

主要文件

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产品名称

可卡因标准液 盐酸盐,

InChI key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

SMILES string

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

form

powder

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
kontrollierte Droge in Deutschland

Quality Level

200

application(s)

forensics and toxicology

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相关类别

Biochem/physiol Actions

分别以大约 300nM、900nM 和 400nM 的 Kis 抑制多巴胺、去甲肾上腺素和 5-羟色胺转运蛋白。不同于苯异丙胺，它不会影响儿茶酚胺的释放。
抑制多巴胺、去甲肾上腺素和 5-羟色胺转运蛋白。

Application

Cocaine hydrochloride has been used:
  • in saline control to study the effects of cocaine self-administration in mouse brain
  • as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
  • to examine conditioning to intravenous cocaine hydrochloride

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3

target_organs

Central nervous system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000507008
0000507007
0000507007
0000507008
0000499351

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Michel Engeln et al.
Biological psychiatry, 87(11), 992-1000 (2019-12-21)
We previously showed that the transcription factor Egr3 (early growth response 3) is oppositely regulated in nucleus accumbens (NAc) cell subtypes 24 hours following cocaine exposure and bidirectionally mediates cocaine-related behaviors in male rodents. Overexpressing Egr3 in D2 receptor-containing medium
Maria E Burkovetskaya et al.
ACS chemical neuroscience, 11(15), 2231-2242 (2020-07-02)
Cocaine addiction remains a major public concern throughout the world especially in developed countries. In the last three decades, significant achievements have led to a greater understanding of the signaling pathways involved in the development of cocaine addiction; however, there
Benoît Forget et al.
Progress in neurobiology, 197, 101898-101898 (2020-08-26)
Cocaine addiction is a chronic and relapsing disorder with an important genetic component. Human candidate gene association studies showed that the single nucleotide polymorphism (SNP) rs16969968 in the α5 subunit (α5SNP) of nicotinic acetylcholine receptors (nAChRs), previously associated with increased
Maria E Burkovetskaya et al.
Neuroscience letters, 728, 134951-134951 (2020-04-13)
The evidence showing the involvement of microglial activation in the development of drug addiction remain scarce as microglia have not been systematically investigated in self-administered mice, a gold standard rodent model for drug addiction. Here we established the stable cocaine
Lauren J Jones et al.
Frontiers in behavioral neuroscience, 9, 246-246 (2015-10-07)
The zebrafish is an ideal model organism for behavioral genetics and neuroscience. The high conservation of genes and neurotransmitter pathways between zebrafish and other vertebrates permits the translation of research between species. Zebrafish behavior can be studied at both larval
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