跳转至内容
Merck
CN

C5808

Cortistatin-14

≥97% (HPLC)

别名:

CST-14, Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C81H113N19O19S2
化学文摘社编号:
186901-48-4
分子量:
1721.01
NACRES:
NA.77
PubChem Substance ID:
329775102
UNSPSC Code:
12352202
MDL number:
MFCD01075120

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

InChI

1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1

SMILES string

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc6ccccc6)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]7CCCN7

InChI key

DDRPLNQJNRBRNY-WYYADCIBSA-N

assay

≥97% (HPLC)

form

powder

mol wt

~_1.7 kDa

packaging

vial of 0.5 mg

solubility

1% acetic acid: 1 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

General description

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. In the peripheral system, it is produced in adrenal, thyroid, parathyroid, stomach, intestine, pancreas, testes, liver and kidney.

Application

Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).

Biochem/physiol Actions

Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.
Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000366416
0000356330
0000342220
0000313481
0000341582

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain
Braun H, et al.
Brain Research, 803(1-2), 54-60 (1998)
J R Criado et al.
Journal of neuroscience research, 56(6), 611-619 (1999-06-22)
Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal function are different from those of somatostatin. We studied the structural basis for
Cortistatin and pituitary hormone secretion in rat
Baranowska B, et al.
Acta Physiologica Polonica, 60(1), 151-151 (2009)
J F Flood et al.
Brain research, 775(1-2), 250-252 (1998-01-24)
Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin-14 were injected intracerebroventricularly after footshock avoidance training
Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems
Markovics A, et al.
Journal of Molecular Neuroscience, 46(1), 40-50 (2012)
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持