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Merck
CN

C5808

Sigma-Aldrich

Cortistatin-14

≥97% (HPLC)

别名:

CST-14, Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

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关于此项目

经验公式（希尔记法）:
C81H113N19O19S2
化学文摘社编号:
186901-48-4
分子量:
1721.01
MDL编号:
MFCD01075120
UNSPSC代码:
12352202
PubChem化学物质编号:
329775102
NACRES:
NA.77

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质量水平

200

方案

≥97% (HPLC)

表单

powder

分子量

~_1.7 kDa

包装

vial of 0.5 mg

溶解性

1% acetic acid: 1 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc6ccccc6)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]7CCCN7

InChI

1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1

InChI key

DDRPLNQJNRBRNY-WYYADCIBSA-N

一般描述

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. In the peripheral system, it is produced in adrenal, thyroid, parathyroid, stomach, intestine, pancreas, testes, liver and kidney.

应用

Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).

生化/生理作用

Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.
Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000366416
0000356330
0000342220
0000313481
0000341582

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Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain
Braun H, et al.
Brain Research, 803(1-2), 54-60 (1998)
J R Criado et al.
Journal of neuroscience research, 56(6), 611-619 (1999-06-22)
Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal function are different from those of somatostatin. We studied the structural basis for
Cortistatin and pituitary hormone secretion in rat
Baranowska B, et al.
Acta Physiologica Polonica, 60(1), 151-151 (2009)
J F Flood et al.
Brain research, 775(1-2), 250-252 (1998-01-24)
Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin-14 were injected intracerebroventricularly after footshock avoidance training
Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems
Markovics A, et al.
Journal of Molecular Neuroscience, 46(1), 40-50 (2012)
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