C5851
CGP 35348 水合物
≥97% (NMR), solid
别名:
(3-氨基丙基)(二乙氧基甲基)次膦酸 水合物
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关于此项目
经验公式（希尔记法）:
C8H20NO4P · xH2O
化学文摘社编号:
分子量:
225.22 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥97% (NMR)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
创始人
Novartis
储存温度
−20°C
SMILES字符串
O.CCOC(OCC)P(O)(=O)CCCN
InChI
1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
InChI key
SRBHGEXMDCJOMS-UHFFFAOYSA-N
应用
CGP 35348水合物已用作γ-氨基丁酸-B (GABAB)受体抑制剂：
- 用于研究其对大鼠海马体内源光信号(IOS)的影响
- 通过单独使用或与水杨酸钠联用，研究其对大鼠背皮层听觉反应的影响
- 研究其对肝细胞癌细胞(HCC)的影响
生化/生理作用
CGP 35348是一种γ-氨基丁酸-B (GABAB)受体拮抗剂。它可穿过血脑屏障，对突触后受体的亲和性比突触前受体更高。
特点和优势
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
免责声明
产品具有吸湿性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
N G Bowery
Annual review of pharmacology and toxicology, 33, 109-147 (1993-01-01)
In conclusion, GABAB receptors appear to be of major importance in synaptic processing within the brain and are present at both post- and presynaptic sites. Their activation can hyperpolarize neurones and diminish neurotransmitter release from presynaptic terminals. We already know
GABAB receptor antagonists: from synthesis to therapeutic applications.
H Bittiger et al.
Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)
Chirag R Patel et al.
Frontiers in neurology, 5, 235-235 (2014-12-03)
Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic
K R Delaney et al.
The European journal of neuroscience, 30(11), 2077-2088 (2010-02-05)
Synaptic responses resulting from stimulation of the main olfactory and vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) of frog, Rana pipiens, to test the hypothesis that properties of these synapses would reflect the distinct differences
Q Gillani et al.
BioMed research international, 2014, 295215-295215 (2014-05-08)
To study the effect of CGP 35348 on learning and memory in albino mice following hypoxia ischemia insult, 10 days old albino mice were subjected to right common carotid artery ligation followed by 8% hypoxia for 25 minutes. Following brain
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