C5857
CA-074 甲基酯
≥99% (TLC)
别名:
(L-3-反式-(丙基氨基甲酰)环氧乙烷-2-甲酰基)-L-异亮氨酰-L-脯氨酸甲酯
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关于此项目
经验公式（希尔记法）:
C19H31N3O6
CAS Number:
分子量:
397.47
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic (organic)
质量水平
方案
≥99% (TLC)
表单
solid
储存温度
−20°C
SMILES字符串
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
InChI
1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
InChI key
XGWSRLSPWIEMLQ-RQLZCWDZSA-N
相关类别
应用
使用CA-074甲酯用作心肌细胞、HeLa细胞和胰腺癌PANC-1细胞中的组织蛋白酶B抑制剂。
生化/生理作用
CA-074甲酯是CA-074的细胞渗透性类似物。它是组织蛋白酶B尤其胞内型的抑制剂，可通过酯酶作用在细胞内转化为活性CA-074。CA-074甲酯还可抑制组织蛋白酶L。
特点和优势
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
The cathepsin B-selective inhibitors CA-074 and CA-074Me inactivate cathepsin L under reducing conditions
Steverding D
Open enzyme inhibition Journal, 4(1), 3493-3500 (2011)
D J Buttle et al.
Archives of biochemistry and biophysics, 299(2), 377-380 (1992-12-01)
The specificity of compound CA074 [N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-pro line] for the inactivation of cathepsin B was quantified in in vitro measurements with cysteine endopeptidases from cattle, it being found that the compound is a very rapid inactivator of cathepsin B (rate constant
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
Zhang C, et al.
Chinese Medical Journal (English Edition), 122(20), 2489-2496 (2009)
Junqing An et al.
Theranostics, 13(9), 2825-2842 (2023-06-07)
Rationale: Nicotine has been reported to be a strong risk factor for atherosclerosis. However, the underlying mechanism by which nicotine controls atherosclerotic plaque stability remain largely unknown. Objective: The aim of this study was to evaluate the impact of lysosomal
An intracellular form of cathepsin B contributes to invasiveness in cancer
Szpaderska AM and Frankfater A
Cancer Research, 61(8), 3493-3500 (2001)
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