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C5874

Cidofovir hydrate

Name: Cidofovir hydrate
Brand: SIGMA

≥98% (HPLC), powder, viral DNA synthesis inhibitor

别名:

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC; Cidovir, HPMPC, Vistide

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经验公式（希尔记法）:

C₈H₁₄N₃O₆P · xH₂O

化学文摘社编号:

113852-37-2

分子量:

279.19 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329775105

NACRES:

NA.77

MDL number:

MFCD17215968

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

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属性

产品名称

Cidofovir hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

solubility

deionized water: ≥5 mg/mL (warmed)

storage temp.

room temp

SMILES string

O.NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1

InChI

1S/C8H14N3O6P.H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);1H2/t6-;/m0./s1

InChI key

KLJYJZIIJLYJNN-RGMNGODLSA-N

说明

Biochem/physiol Actions

Selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315

pcodes

P264 - P280 - P301 + P310 - P302 + P352 - P332 + P313 - P362 + P364

Hazard Classifications

Acute Tox. 3 Oral - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Discover Bioactive Small Molecules for ADME/Tox

Safety and tolerance of cidofovir as a 2% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation.

Michel Bossens et al.

International journal of clinical pharmacology and therapeutics, 56(3), 134-141 (2018-01-11)

The primary objective was to evaluate the safety and local tolerance of a topical 2% (w/w) cidofovir gel, applied directly to the cervices of women with high-grade cervical intraepithelial neoplasia (CIN 2+). The secondary objective was to evaluate the pharmacokinetics

A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus.

Stephen D S McCarthy et al.

PLoS neglected tropical diseases, 10(1), e0004364-e0004364 (2016-01-12)

To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult

Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.

Vinod E Nambudiri et al.

JAMA dermatology, 149(9), 1068-1070 (2013-07-05)

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全球贸易项目编号

货号	GTIN
C5874-50MG	04061832631851
C5874-10MG	04061832631844