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COO原产地证书/COA分析证书

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C5923

(-)-可替宁

Name: (-)-可替宁
Brand: SIGMA

≥98% (TLC), crystals, nicotine metabolite

别名:

(S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮, S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮

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About This Item

经验公式（希尔记法）:

C₁₀H₁₂N₂O

CAS Number:

486-56-6

分子量:

176.22

Beilstein:

83099

EC 号:

207-634-9

MDL编号:

MFCD00077696

UNSPSC代码:

12352200

PubChem化学物质编号:

24278324

NACRES:

NA.77

Product Name

(-)-可替宁, ≥98%

质量水平

200

方案

≥98%

表单

crystals

沸点

250 °C/150 mmHg (lit.)

mp

40-42 °C (lit.)

储存温度

2-8°C

SMILES字符串

CN1[C@@H](CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChI key

UIKROCXWUNQSPJ-VIFPVBQESA-N

基因信息

human ... CYP1A2(1544), CYP2A6(1548)
mouse ... Cyp2a5(13087)

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一般描述

Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD).

应用

Cotinine has been used:

for oxygen-glucose deprivation (OGD) studies to model ischemic stroke
as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
to evaluate the adverse developmental potential of cotinine
to assess cognitive behavior in mice

生化/生理作用

尼古丁在人体内的主要代谢物。

象形图

GHS07

警示用语：

Warning

危险声明

H302,H315,H319,H335

预防措施声明

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

230.0 °F - closed cup

闪点(°C)

110 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000395811

0000360747

0000347095