C6012
胆甾-3,5-二烯
≥93% (HPLC)
别名:
Δ3,5-Cholestadiene, Cholesterilene
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关于此项目
经验公式（希尔记法）:
C27H44
化学文摘社编号:
分子量:
368.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
EC Number:
212-021-4
MDL number:
产品名称
胆甾-3,5-二烯, ≥93% (HPLC)
InChI key
RLHIRZFWJBOHHD-HKQCOZBKSA-N
InChI
1S/C27H44/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h6,11-12,19-20,22-25H,7-10,13-18H2,1-5H3/t20-,22+,23-,24+,25+,26+,27-/m1/s1
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C=CCC[C@]4(C)[C@H]3CC[C@]12C
biological source
natural (organic)
assay
≥93% (HPLC)
form
powder
mp
78-80 °C (lit.)
shipped in
ambient
storage temp.
−20°C
Quality Level
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Application
胆固醇-3，5-二烯被用作 HPLC 法对不同类型的橄榄油和食用脂肪进行质量分析中的标准品。
Biochem/physiol Actions
胆甾-3，5-二烯是一种氧固醇，一种通过自氧化的胆固醇衍生物。Oxysterols 是胆固醇稳态的非基因组调节因子。它的生物学作用有蛋白质异戊烯化、细胞凋亡、鞘脂代谢调节和血小板聚集。氧固醇与肝 X 受体结合，调节胆固醇流出并减少细胞对胆固醇的摄取。
Preparation Note
胆甾-3，5-二烯在 50mg/ml 的氯仿中生成澄清无色的溶液。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Determination of Edible Fat Refining by HPLC of δ 3, 5?Steradienes
Schulte E
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Agata A Bielska et al.
Trends in endocrinology and metabolism: TEM, 23(3), 99-106 (2012-01-17)
Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives
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