C6013
胆甾醇半琥珀酸酯 三羟甲基氨基甲烷盐
anionic detergent
别名:
3β-Hydroxy-5-cholestene 3-hemisuccinate, CHEMS, CHS, 胆固醇半琥珀酸酯, 胆甾醇琥珀酸酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C31H50O4 · C4H11NO3
化学文摘社编号:
分子量:
607.86
UNSPSC Code:
12352211
eCl@ss:
39023139
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
胆甾醇半琥珀酸酯 三羟甲基氨基甲烷盐, anionic detergent
SMILES string
NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
InChI key
SLDYONDUXRBLLR-XTCKSVDZSA-N
InChI
1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
functional group
ester
shipped in
ambient
storage temp.
−20°C
Quality Level
Application
胆固醇半琥珀酸酯三盐用于：
- 制备用于葡聚糖合酶测定的溶解缓冲液
- 制备用于将阿片受体固定在顺磁珠上的免疫沉淀缓冲液。
- 作为脂质体和蛋白突触结合蛋白1的膜稳定剂
- 作为叶酸修饰的自微乳化药物递送系统的组成部分。
- 与正十二烷基 β-D-麦芽糖苷（DDM）一起用于溶解红细胞血影和趋化因子受体CCR1
- 用于溶解蛋白
Biochem/physiol Actions
胆固醇半琥珀酸盐是一种可电离的阴离子洗涤剂，可稳定大的单层囊泡。这些脂质体囊泡作为抗癌药物、寡核苷酸和抗生素的递送剂。据报道胆固醇琥珀酸酯还具有抗增殖活性，并可以在临床上用作抗肿瘤剂。
Preparation Note
浓度为1 mg/ml的半琥珀酸胆固醇三盐在甲醇中生成澄清、无色的溶液。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
P Mazur et al.
The Journal of biological chemistry, 271(24), 14604-14609 (1996-06-14)
In the yeast Saccharomyces cerevisiae, the family of RHO genes are implicated in the control of morphogenetic events although the molecular targets of these GTP-binding proteins remain largely unknown. The activity of 1,3-beta-D-glucan synthase, the product of which is essential
David Ott et al.
Protein engineering, design & selection : PEDS, 18(3), 153-160 (2005-03-26)
Opioid receptors, like many G protein-coupled receptors (GPCRs), are notoriously unstable in detergents. We have now developed a more stable variant of the mu-opioid receptor (MOR) and also a method for the immobilization of solubilized, functional opioid receptors on a
Samantha J Allen et al.
Protein expression and purification, 66(1), 73-81 (2009-03-12)
Chemokine receptors are a specific class of G-protein-coupled receptors (GPCRs) that control cell migration associated with routine immune surveillance, inflammation and development. In addition to their roles in normal physiology, these receptors and their ligands are involved in a large
I M Hafez et al.
Biophysical journal, 79(3), 1438-1446 (2000-09-02)
The pH-dependent fusion properties of large unilamellar vesicles (LUVs) composed of binary mixtures of anionic and cationic lipids have been investigated. It is shown that stable LUVs can be prepared from the ionizable anionic lipid cholesteryl hemisuccinate (CHEMS) and the
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
Ding, W.X., et al.
International Journal of Pharmaceutics, 300, 37-47 (2005)
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