C6240
CITCO
≥98% (HPLC), androstane receptor agonist, solid
别名:
6-（4-氯苯基）咪唑并[2，1-b][1，3]噻唑-5-甲醛O-（3，4-二氯苄基）肟
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关于此项目
经验公式（希尔记法）:
C19H12N3OCl3S
化学文摘社编号:
分子量:
436.74
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CITCO, ≥98% (HPLC), solid
SMILES string
Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI key
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
InChI
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: soluble 28 mg/mL, H2O: insoluble
storage temp.
−20°C
Quality Level
General description
CITCO是一种咪唑并噻唑衍生物。它刺激人类组成型雄烷受体（CAR）核易位。
Application
CITCO已用于小鼠组成型雄烷受体（CAR）和人CAR的激活。
Biochem/physiol Actions
CITCO是组成型雄烷受体（CAR）激动剂；核受体NR113激动剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss
Tschuor C, et l.
Journal of Hepatology, 65(1), 66-74 (2016)
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Won-Gu Choi et al.
Pharmaceutics, 12(3) (2020-03-07)
Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody-drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5'-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression of cytochrome P450s
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