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Merck
CN

C6305

氯氮平标准液

≥98% (TLC), powder, D₄-dopamine receptor antagonist

别名:

8-氯-11-（4-甲基-1-哌嗪基）-5H-二苯并[b,e][1,4]二氮杂卓

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关于此项目

经验公式（希尔记法）:
C18H19ClN4
化学文摘社编号:
5786-21-0
分子量:
326.82
UNSPSC Code:
12352200
PubChem Substance ID:
24277892
NACRES:
NA.77
MDL number:
MFCD00153785

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产品名称

氯氮平标准液,

SMILES string

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

QZUDBNBUXVUHMW-UHFFFAOYSA-N

form

powder

solubility

ethanol: 1 mg/mL
0.1 M HCl: 30 mg/mL
DMSO: 4.8 mg/mL

originator

Novartis

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

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相关类别

Biochem/physiol Actions

非典型抗精神病化合物。D 4 -多巴胺受体的选择性拮抗剂。5-HT2A、5-HT2C、5-HT3、 5-HT6和 5-HT7 5-羟色胺受体拮抗剂。

Features and Benefits

《受体分类和信号转导》手册的 组胺受体 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由Novartis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000508212
0000508212
0000445523
0000445523
0000424163

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