Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse

The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.

human CXCR2 transfected NSO mouse myeloma cells.

CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Purified using protein G.

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