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Merck
CN

C6352

CTAP

≥95%

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关于此项目

经验公式（希尔记法）:
C51H69N13O11S2
化学文摘社编号:
103429-32-9
分子量:
1104.30
NACRES:
NA.32
PubChem Substance ID:
329775120
UNSPSC Code:
12352200
MDL number:
MFCD00671434

主要文件

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产品名称

CTAP, ≥95%

InChI

1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

SMILES string

C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O

InChI key

OFMQLVRLOGHAJI-FGHAYEPSSA-N

assay

≥95%

form

powder

UniProt accession no.

Q62923

storage temp.

−20°C

Quality Level

200

Gene Information

rat ... Pnoc(25516)

Application

CTAP可作为μ-阿片受体 (MOR) 拮抗剂用于：
  • 研究二肽基肽酶4 (DPP4) 抑制剂异亮氨酰-脯氨酰-异亮氨酸 (IPI) 和维格列汀对卡拉胶诱导炎症的抗痛觉过敏作用
  • 研究其在大鼠天敌应激期间对谷氨酸和γ-氨基丁酸 (GABA) 外排的作用
  • 测定在胃泌素释放肽 (Grp+) 神经元活化诱导疼痛阻断中参与的內源性阿片肽

Biochem/physiol Actions

CTAP是以生长抑素类似物制备的一种多肽拮抗剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL7841
BCCF0591
BCCC0540
BCBV7821
BCBS0886V

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T J Abbruscato et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 402-409 (1997-01-01)
D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) is a cyclic, penicillamine-containing octapeptide that is structurally similar to somatostatin and displays greater antagonist potency and selectivity for mu-opioid receptors, compared with the classical mu-selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2. The aim of this study was to determine whether CTAP
Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord
Sun S, et al.
Neuron, 93(4), 840-853 (2017)
Chloe M Stanton et al.
Scientific reports, 7(1), 12147-12147 (2017-09-25)
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular
Kevin Caref et al.
eLife, 7 (2018-03-28)
When relatively sated, people (and rodents) are still easily tempted to consume calorie-dense foods, particularly those containing fat and sugar. Consumption of such foods while calorically replete likely contributes to obesity. The nucleus accumbens (NAc) opioid system has long been
Potency Differences ford-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2as an Antagonist of Peptide and Alkaloid mu-Agonists in an Antinociception Assay
Sterious SN and Walker EA
Journal of Pharmacology and Experimental Therapeutics, 304(1), 301-309 (2003)
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