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Merck
CN

C6473

Monoclonal Anti-CXCR3 antibody produced in mouse

clone 49801.111, purified immunoglobulin, lyophilized powder

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关于此项目

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
49801.111, monoclonal
Application:
FACS
Citations:
3
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

49801.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCR3(2833)
mouse ... Cxcr3(12766)

General description

Chemokine receptor CXCR3 also refers as IP -10 or Mig receptor is a Gαi protein-coupled receptor and is highly expressed by IL-2-activated T lymphocytes (Th1). It facilitates calcium mobilization and chemotaxis. It also plays a pivotal role in wound healing. Monoclonal Anti-CXCR3 antibody can be used in flow cytometry for the Identification of CXCR-3. Mouse anti-CXCR3 antibody reacts specifically with CXCR-3 transfected cells but not with the parent cell line. The product has shown no cross-reactivity with human CXCR-1, CXCR-2 and CXCR-4.

Immunogen

human CXCR3 transfected NSO mouse myeloma cells.

Application

Monoclonal Anti-CXCR3 antibody can be used as a positive control in immunohistochemical staining.

Biochem/physiol Actions

The antibody reacts with human CXCR3 transfectant cells and not the parent cell line. It has no cross-reactivity with CXCR1, CXCR2, or CXCR4.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Anja Mueller et al.
Journal of leukocyte biology, 83(4), 875-882 (2008-01-05)
The chemokine CXCL4/platelet factor-4 is released by activated platelets in micromolar concentrations and is a chemoattractant for leukocytes via an unidentified receptor. Recently, a variant of the human chemokine receptor CXCR3 (CXCR3-B) was described, which transduced apoptotic but not chemotactic
Cecelia C Yates et al.
The American journal of pathology, 171(2), 484-495 (2007-06-30)
Replacement of wounded skin requires the initially florid cellular response to abate and even regress as the dermal layer returns to a relatively paucicellular state. The signals that direct this "stop and return" process have yet to be deciphered. CXCR3
S Kobayashi et al.
Rheumatology (Oxford, England), 47(9), 1317-1322 (2008-07-12)
Environmental factors are involved in RA pathogenesis and epidemiological studies have suggested that smoking is an environmental risk factor for RA. The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking



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货号GTIN
C6473-.5MG04061832714042