C6506
4-氯-DL-苯丙氨酸
5-HT synthesis inhibitor, solid
别名:
PCP, PCPA
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关于此项目
线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
产品名称
4-氯-DL-苯丙氨酸,
form
solid
Quality Level
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
>240 °C (dec.) (lit.)
greener alternative category
storage temp.
room temp
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“危险性较小的化学合成”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。
Application
4-氯-DL-苯丙氨酸用于：
- 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼
- 在大鼠模型中诱发失眠
- 处理胚胎，检查其对5-羟色胺的影响
- 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体
- 饲喂苍蝇，研究5-羟色胺的作用
Biochem/physiol Actions
4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。
色氨酸羟化酶抑制剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
In silico analysis and experimental validation of lignan extracts from kadsura longipedunculata for potential 5-HT1AR agonists
Zheng Y, et al.
PLoS ONE, 10(6), e0130055-e0130055 (2015)
Dopamine and serotonin are both required for mate-copying in Drosophila melanogaster
Monier M, et al.
Frontiers in Behavioral Neuroscience, 12(5), 334-334 (2018)
Enhancement of the antibacterial activity of an E. faecalis strain by the heterologous expression of enterocin A
Serrano-Maldonado C E and Quirasco M
Journal of Biotechnology, 283(5), 28-36 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C6506-25G | 04061833618899 |
| C6506-5G | 04061833511305 |