C6643
氯贝丁酯
liquid
别名:
氯贝特
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关于此项目
经验公式（希尔记法）:
C12H15ClO3
化学文摘社编号:
分子量:
242.70
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
211-277-4
Beilstein/REAXYS Number:
1913459
MDL number:
Form:
liquid
form
liquid
Quality Segment
color
clear colorless
density
1.14 g/mL at 25 °C (lit.)
originator
Wyeth
storage temp.
2-8°C
SMILES string
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
InChI
1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key
KNHUKKLJHYUCFP-UHFFFAOYSA-N
Gene Information
human ... PPARA(5465)
mouse ... Ppara(19013)
Application
Clofibrate has been used:
- as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
- as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
- as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes
Biochem/physiol Actions
Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter