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Merck
CN

C6770

卡巴多

别名:

2-(喹喔啉-2-亚甲基)肼-羧酸甲酯- N,N′-二氧化物

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关于此项目

经验公式(希尔记法):
C11H10N4O4
化学文摘社编号:
分子量:
262.22
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
229-879-0
MDL number:
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InChI key

OVGGLBAWFMIPPY-WUXMJOGZSA-N

InChI

1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+

SMILES string

COC(=O)N\N=C\c1cn(=O)c2ccccc2n1=O

form

powder

solubility

1 M NaOH: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Application

卡巴多司已被用于抑制醛固酮的产生,研究产生志贺毒素的大肠杆菌(STEC)菌株的传播,以及比较不同的抗菌活性。

Biochem/physiol Actions

卡巴多司是一种喹喔啉二氧化氮抗生素,通常用在猪饲料中预防痢疾并提高饲料效率。它通过插入和诱导细菌基因组中的突变来抑制细菌。

Other Notes

保存于密闭容器内,置于干燥通风处。

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Flam. Sol. 1

存储类别

4.1B - Flammable solid hazardous materials

wgk

WGK 3

flash_point_f

64.4 °F - closed cup

flash_point_c

18 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Amisha D Shah et al.
Environmental science & technology, 40(23), 7228-7235 (2006-12-22)
The potential release of carbadox (CDX), a commonly used antibacterial agent in swine husbandry, into water systems is of a concern due to its carcinogenic and genotoxic effects. Until this study, the reactivity of carbadox (possessing quinoxaline N,N'-dioxide and hydrazone
M C Walsh et al.
Journal of animal science, 90(8), 2599-2608 (2012-02-22)
The objective of this study was to evaluate the effects of water-delivered, direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs after deliberate Salmonella infection. Pigs (n = 88) were weaned at 19
Thaddeus B Stanton et al.
Applied and environmental microbiology, 74(10), 2950-2956 (2008-03-25)
Brachyspira hyodysenteriae is an anaerobic spirochete and the etiologic agent of swine dysentery. The genome of this spirochete contains a mitomycin C-inducible, prophage-like gene transfer agent designated VSH-1. VSH-1 particles package random 7.5-kb fragments of the B. hyodysenteriae genome and
T Hayashi et al.
Antimicrobial agents and chemotherapy, 32(4), 458-461 (1988-04-01)
Sedecamycin (lankacidin A), one of the lankacidin-group antibiotics, showed potent activity against Treponema hyodysenteriae. The MICs of sedecamycin against 79 field isolates of T. hyodysenteriae ranged from 0.78 to 12.5 micrograms/ml, the MIC for 90% of the strains tested (MIC90)
Torey Looft et al.
Frontiers in microbiology, 5, 276-276 (2014-06-25)
Antibiotics are used in livestock and poultry production to treat and prevent disease as well as to promote animal growth. Carbadox is an in-feed antibiotic that is widely used in swine production to prevent dysentery and to improve feed efficiency.

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