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Merck
CN

C6780

α-酪蛋白 来源于牛奶

≥70% αs-casein basis (electrophoresis), lyophilized powder

别名:

alpha-S1-casein, alpha-S2-casein

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关于此项目

化学文摘社编号:
9000-71-9
UNSPSC Code:
12352202
NACRES:
NA.61
EC Number:
232-555-1
MDL number:
MFCD00130477
Form:
lyophilized powder
Assay:
≥70% αs-casein basis (electrophoresis)
Biological source:
bovine milk

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SMILES string

[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

biological source

bovine milk

assay

≥70% αs-casein basis (electrophoresis)

form

lyophilized powder

technique(s)

mass spectrometry (MS): suitable

UniProt accession no.

P02662, P02663

storage temp.

−20°C

Quality Level

200

Gene Information

cow ... CSN1(282208), CSN1S2(282209)

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Application

来自牛乳的α-酪蛋白是一种免疫球蛋白 E (IgE) 结合表位，属于酪蛋白磷蛋白家族。由于α-酪蛋白抗体与胰岛素的强烈交叉反应性，它已用于儿童胰岛素依赖型糖尿病 (IDDM) 的研究。对儿童表现 (IDDM) 的研究显示，与对照兄弟姐妹相比，α-酪蛋白抗体水平更高，这可能作为 IDDM 的风险标志物。

Biochem/physiol Actions

α;-酪蛋白可以是幼儿的免疫原，抗 a-酪蛋白抗体与胰岛素有较强的交叉反应性。这种效应可以解释不常见的胰岛素自身免疫，但似乎不会发展为 I 型糖尿病。

Preparation Note

色谱纯化产品

存储类别

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000356680
0000356680
0000523441
0000523442
0000523441

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Richard D Unwin et al.
Nature protocols, 4(6), 870-877 (2009-05-16)
The application of a targeted mass spectrometric workflow to the sensitive identification of post-translational modifications is described. This protocol employs multiple reaction monitoring (MRM) to search for all putative peptides specifically modified in a target protein. Positive MRMs trigger an
T Saukkonen et al.
Diabetologia, 41(1), 72-78 (1998-03-14)
Dietary factors are suspected to play an aetiological role in the development of insulin-dependent diabetes mellitus (IDDM). We analysed cow's milk formula, betalactoglobulin, and bovine serum albumin antibodies by an enzyme-linked immunoassay in unselected children with newly diagnosed IDDM and
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K Adler et al.
Clinical and experimental immunology, 164(1), 42-49 (2011-03-03)
Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA.
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