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Merck
CN

C6780

Sigma-Aldrich

α-酪蛋白 来源于牛奶

≥70% αs-casein basis (electrophoresis), lyophilized powder

别名:

alpha-S1-casein, alpha-S2-casein

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关于此项目

CAS Number:
9000-71-9
EC 号:
232-555-1
MDL编号:
MFCD00130477
UNSPSC代码:
12352202
NACRES:
NA.61

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生物来源

bovine milk

质量水平

200

方案

≥70% αs-casein basis (electrophoresis)

表单

lyophilized powder

技术

mass spectrometry (MS): suitable

UniProt登记号

P02662
P02663

储存温度

−20°C

SMILES字符串

[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

基因信息

cow ... CSN1(282208), CSN1S2(282209)

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应用

来自牛乳的α-酪蛋白是一种免疫球蛋白 E (IgE) 结合表位，属于酪蛋白磷蛋白家族。由于α-酪蛋白抗体与胰岛素的强烈交叉反应性，它已用于儿童胰岛素依赖型糖尿病 (IDDM) 的研究。对儿童表现 (IDDM) 的研究显示，与对照兄弟姐妹相比，α-酪蛋白抗体水平更高，这可能作为 IDDM 的风险标志物。

生化/生理作用

α;-酪蛋白可以是幼儿的免疫原，抗 a-酪蛋白抗体与胰岛素有较强的交叉反应性。这种效应可以解释不常见的胰岛素自身免疫，但似乎不会发展为 I 型糖尿病。

制备说明

色谱纯化产品

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000476919
0000476943
0000476943
0000476919
0000447097

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T Saukkonen et al.
Diabetologia, 41(1), 72-78 (1998-03-14)
Dietary factors are suspected to play an aetiological role in the development of insulin-dependent diabetes mellitus (IDDM). We analysed cow's milk formula, betalactoglobulin, and bovine serum albumin antibodies by an enzyme-linked immunoassay in unselected children with newly diagnosed IDDM and
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Richard D Unwin et al.
Nature protocols, 4(6), 870-877 (2009-05-16)
The application of a targeted mass spectrometric workflow to the sensitive identification of post-translational modifications is described. This protocol employs multiple reaction monitoring (MRM) to search for all putative peptides specifically modified in a target protein. Positive MRMs trigger an
Serena Di Palma et al.
Nature protocols, 7(11), 2041-2055 (2012-10-27)
Multidimensional liquid chromatography (LC) combined with mass spectrometry (MS) has become a standard technique in proteomics to reduce sample complexity and to tackle the dynamic range in protein abundance. Fractionation is necessary to obtain a comprehensive analysis of complex biological
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