C6869
Anti-CCRK (381-395) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-CDCH, Anti-Cell cycle related kinase isoform 2 (Homo sapiens), Anti-p42
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~36 kDa
种属反应性
human
技术
western blot: 1:500-1:2,000
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCRK(23552)
免疫原
synthetic peptide corresponding to amino acids 381-395 of human CCRK.
应用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CCRK (381-395) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
生化/生理作用
Cell cycle-related kinase (CCRK) is a protein kinase that is homologous to Cdk7. It is a candidate for oncogene in human glioblastoma tumorigenesis. CCRK is also involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. CCRK plays an important role in the control of cell proliferation via the regulation of cyclin D1 expression, and the overexpression of CCRK. It also acts as an independent molecular marker for shortened survival time of patients with ovarian carcinoma. CCRK along with its substrate ICK (intestinal cell kinase) inhibits ciliogenesis and glioblastoma cell proliferation. Depletion of CCRK leads to accumulation of ICK at ciliary tips, altered ciliary transport and leads to inhibition of cell cycle re-entry in NIH3T3 fibroblasts.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Ying Yang et al.
EMBO reports, 14(8), 741-747 (2013-06-08)
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (intestinal
Guo-Qing Wu et al.
International journal of cancer, 125(11), 2631-2642 (2009-08-13)
Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression
Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis.
Xiaomeng An et al.
European journal of cancer (Oxford, England : 1990), 46(9), 1752-1761 (2010-05-15)
Cell cycle-related kinase (CCRK) is a newly identified protein kinase homologous to Cdk7. We have previously shown that CCRK is a candidate oncogene in human glioblastoma. However, whether CCRK is a bona fide oncogene remains to be tested. The aim
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