C7041
McN-A-343
≥98% (TLC)
别名:
(4-羟基-2-丁炔基)-1-三甲基铵-3-氯苯基氨基甲酸酯氯化物, 4-[N-(3-氯苯基)氨基甲酰氧]-2-丁炔基三甲基氯化铵
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关于此项目
经验公式（希尔记法）:
C14H18Cl2N2O2
化学文摘社编号:
分子量:
317.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
McN-A-343, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
color
off-white
solubility
H2O: soluble
ethanol: soluble
InChI
1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
SMILES string
[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1
InChI key
CXFZFEJJLNLOTA-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
rat ... Chrm1(25229)
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Biochem/physiol Actions
M1 毒蕈碱型乙酰胆碱受体激动剂。
Preparation Note
Solutions may be stored for several days at 4 °C.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Lauren T May et al.
Molecular pharmacology, 72(2), 463-476 (2007-05-26)
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonists, as opposed to modulators
Dedmer Schaafsma et al.
British journal of pharmacology, 147(7), 737-743 (2006-01-25)
In airway smooth muscle (ASM), full and partial muscarinic receptor agonists have been described to have large differences in their ability to induce signal transduction, including Ca2+-mobilization. Despite these differences, partial agonists are capable of inducing a submaximal to maximal
Hinako Suga et al.
Molecular pharmacology, 78(4), 745-755 (2010-07-21)
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this
Laura Oliveira et al.
Neuro-Signals, 14(5), 262-272 (2005-11-23)
At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C
Hinako Suga et al.
The Journal of pharmacology and experimental therapeutics, 327(2), 518-528 (2008-08-07)
We explored the interaction of a nitrogen mustard derivative of acetylcholine with the human M(2) muscarinic receptor expressed in Chinese hamster ovary cells using the muscarinic radioligand, [3H]N-methylscopolamine (NMS). Acetylcholine mustard caused a concentration-dependent, first-order loss of [3H]NMS binding at
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