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C7041

McN-A-343

Name: McN-A-343
Brand: SIGMA

≥98% (TLC)

别名:

(4-羟基-2-丁炔基)-1-三甲基铵-3-氯苯基氨基甲酸酯氯化物, 4-[N-(3-氯苯基)氨基甲酰氧]-2-丁炔基三甲基氯化铵

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₈Cl₂N₂O₂

化学文摘社编号:

55-45-8

分子量:

317.21

NACRES:

NA.77

PubChem Substance ID:

24277827

UNSPSC Code:

12352106

MDL number:

MFCD00055068

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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属性

Quality Level

200

assay

≥98% (TLC)

form

powder

color

off-white

solubility

H₂O: soluble, ethanol: soluble

SMILES string

[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1

InChI

1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H

InChI key

CXFZFEJJLNLOTA-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
rat ... Chrm1(25229)

说明

Biochem/physiol Actions

M₁ 毒蕈碱型乙酰胆碱受体激动剂。

Preparation Note

Solutions may be stored for several days at 4 °C.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protein kinase A and Ca(v)1 (L-Type) channels are common targets to facilitatory adenosine A2A and muscarinic M1 receptors on rat motoneurons.

Laura Oliveira et al.

Neuro-Signals, 14(5), 262-272 (2005-11-23)

At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C

Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343.

Hinako Suga et al.

Molecular pharmacology, 78(4), 745-755 (2010-07-21)

Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this

The pharmacology of McN-A-343.

Frederick J Mitchelson

Pharmacology & therapeutics, 135(2), 216-245 (2012-05-31)

The unusual pharmacology of McN-A-343 was first described by Roszowski in 1961. The agonist appeared to be a selective stimulant of muscarinic receptors in sympathetic ganglia, now known to be the muscarinic M₁ receptor subtype. However, subsequent research demonstrated that

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全球贸易项目编号

货号	GTIN
C7041-25MG	04061833511862
C7041-100MG	04061833511855

主要文件

McN-A-343

≥98% (TLC)

选择尺寸

关于此项目

Quality Level

assay

form

color

solubility

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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