C7270
头孢孟多酯钠
~95%
别名:
Cefamandole formate sodium salt
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关于此项目
线性分子式:
C19H17N6O6S2Na
化学文摘社编号:
分子量:
512.49
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
255-877-4
MDL number:
InChI key
ICZOIXFFVKYXOM-YCLOEFEOSA-M
InChI
1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1
SMILES string
[Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](OC=O)c4ccccc4)C3=O)C([O-])=O
assay
~95%
mode of action
cell wall synthesis | interferes
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General description
Chemical structure: β-lactam
Application
Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefamandole nafate inhibits bacterial cell wall synthesis by inhibiting PBP 2A and other penicillin-binding proteins. Cefamandole nafate has been shown to be rapidly converted to cefamandolein bacteriological media .
Physical form
sodium carbonate: approx. 5%
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
R Gonen et al.
Obstetrics and gynecology, 67(4), 545-548 (1986-04-01)
The efficacy of intraoperative irrigation with cefamandole nafate at cesarean section was evaluated in a prospective, randomized double-blind study. Two hundred and eight patients were treated with antibiotic irrigation and intravenous placebo or with perioperative intravenous cefamandole and irrigated with
M B Henley et al.
Clinical orthopaedics and related research, (209)(209), 249-254 (1986-08-01)
A prospective, randomized, double-blind study was conducted to determine the efficacy of cefamandole nafate in reducing infections in general orthopedic procedures. Of 743 patients initially entered into the study, 715 (362 on cefamandole, 353 on placebo) fulfilled the requirements of
D H Livingston et al.
Surgery, gynecology & obstetrics, 168(2), 138-142 (1989-02-01)
Hemorrhagic shock has been associated with an increased risk of infection after injury. The immediate and long term effects of hemorrhagic shock without tissue injury on the susceptibility of an animal to infection and the efficacy of antibiotic prophylaxis to
R S Bennion et al.
The Journal of cardiovascular surgery, 26(3), 270-274 (1985-05-01)
A blinded, randomized, prospective study of 38 chronic renal failure patients was done to evaluate perioperative antibiotics in the prevention of postoperative infection of vascular access prostheses. Expanded polytetrafluoroethylene (PTFE) hemodialysis grafts were placed either in radiocephalic (19) or femorosaphenous
P B Issopoulos et al.
Acta pharmaceutica Hungarica, 66(2), 89-94 (1996-03-01)
A sensitive, accurate, precise and the same time simple and rapid method for the colorimetric determination of some cephalosporins of the second and third generations, such as: cefoxitin sodium (CFXT), cefaclor (CFCL), cefamandole nafate (CFMD), ceforanide l-lysine (CFRN), cefotaxime sodium
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