C7291
氯米帕明 盐酸盐
≥98% (HPLC), powder
别名:
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H23ClN2 · HCl
化学文摘社编号:
分子量:
351.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
241-344-3
MDL number:
InChI key
WIMWMKZEIBHDTH-UHFFFAOYSA-N
InChI
1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
SMILES string
Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: 25 mg/mL, 0.1 M HCl: soluble
originator
Novartis
Quality Level
Gene Information
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General description
Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.
Application
Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
- to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
- to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
- as a serotonin reuptake inhibitor
- as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor
Biochem/physiol Actions
Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.
Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system, Central nervous system,Cardiovascular
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Child and Adolescent Clinical Psychopharmacology (2007)
E Gur et al.
The Journal of pharmacology and experimental therapeutics, 288(1), 81-87 (1998-12-23)
Augmentation of tricyclic antidepressant (TCA) treatment with triiodothyronine (T3) has been shown to potentiate the therapeutic effect of TCA drugs in depressed patients. We have attempted to elucidate the mechanism of this potentiation by determining the effects of T3 alone
Influence of antidepressant clomipramine hydrochloride drug on human serum albumin: spectroscopic study
Rub MA, et al.
Journal of Molecular Liquids, 241, 91-98 (2017)
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
Koszela J, et al.
BMC biology, 16(1), 88-88 (2018)
M Fujita et al.
European journal of nuclear medicine, 24(4), 403-408 (1997-04-01)
Many reports support the concept of serotonergic-dopaminergic interaction in the brain. However, at present, there are few methods to study this relationship in vivo. The purpose of this study was to investigate the effect of serotonin (5-HT) uptake inhibitor, clomipramine
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