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Merck
CN

C7291

Sigma-Aldrich

氯米帕明 盐酸盐

≥98% (HPLC), powder

别名:

3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride

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关于此项目

经验公式（希尔记法）:
C19H23ClN2 · HCl
化学文摘社编号:
17321-77-6
分子量:
351.31
EC 号:
241-344-3
MDL编号:
MFCD00069234
UNSPSC代码:
12352116
PubChem化学物质编号:
24278087
NACRES:
NA.77

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质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

H2O: 25 mg/mL
0.1 M HCl: soluble

创始人

Novartis

SMILES字符串

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

基因信息

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

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相关类别

一般描述

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

应用

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
  • to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
  • to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
  • as a serotonin reuptake inhibitor
  • as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

生化/生理作用

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.
Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

靶器官

Central nervous system, Central nervous system,Cardiovascular

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
MKCQ6279
MKCJ8350
MKBV9663V
MKBS8660V
SLBD2368V

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Influence of antidepressant clomipramine hydrochloride drug on human serum albumin: spectroscopic study
Rub MA, et al.
Journal of Molecular Liquids, 241, 91-98 (2017)
E Gur et al.
The Journal of pharmacology and experimental therapeutics, 288(1), 81-87 (1998-12-23)
Augmentation of tricyclic antidepressant (TCA) treatment with triiodothyronine (T3) has been shown to potentiate the therapeutic effect of TCA drugs in depressed patients. We have attempted to elucidate the mechanism of this potentiation by determining the effects of T3 alone
Child and Adolescent Clinical Psychopharmacology (2007)
Clomipramine
McTavish D and Benfield P
Drugs, 39(1), 136-153 (1990)
Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid
Li X, et al.
Scientific reports, 7, 41358-41358 (2017)
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