Name: 氯米帕明 盐酸盐
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₉H₂₃ClN₂ · HCl

CAS Number:

17321-77-6

分子量:

351.31

EC 号:

241-344-3

MDL编号:

MFCD00069234

UNSPSC代码:

12352116

PubChem化学物质编号:

24278087

NACRES:

NA.77

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质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

H₂O: 25 mg/mL
0.1 M HCl: soluble

创始人

Novartis

SMILES字符串

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

基因信息

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

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一般描述

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

应用

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.

Clomipramine hydrochloride has been used:

to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
as a serotonin reuptake inhibitor
as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

生化/生理作用

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.