C7374
CK-636
≥98% (HPLC)
别名:
CK-0944636;2-噻吩甲酰胺
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关于此项目
经验公式（希尔记法）:
C16H16N2OS
化学文摘社编号:
分子量:
284.38
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
CK-636, ≥98% (HPLC)
InChI
1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
SMILES string
Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
InChI key
ACAKNPKRLPMONU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
peach to light pink
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
CK-636 抑制肌动蛋白相关蛋白 (Arp) 2/3 复合物的活性；结合在 Arp2 和 Arp3 之间，阻断 Arp2 和 Arp3 的运动进入活性构象，抑制成核肌动蛋白丝的能力。
CK-636 结合在 Arp2 和 Arp3 之间，似乎阻碍 Arp2 和 Arp3 进入其活性构象。CK-636 插入 Arp3 的疏水核心并改变其构象。这两类化合物均抑制李斯特菌形成肌动蛋白丝彗尾和单核细胞形成伪足。
Charlotte Ford et al.
PLoS pathogens, 14(5), e1007051-e1007051 (2018-05-05)
Pathogens hijack host endocytic pathways to force their own entry into eukaryotic target cells. Many bacteria either exploit receptor-mediated zippering or inject virulence proteins directly to trigger membrane reorganisation and cytoskeletal rearrangements. By contrast, extracellular C. trachomatis elementary bodies (EBs)
Liang Ma et al.
Cell research, 25(1), 24-38 (2014-10-25)
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate
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