C7479
Anti-Calretinin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-CAB29, Anti-CAL2, Anti-CR
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
microarray
western blot
microarray
western blot
Species reactivity:
rat, human, chicken
Citations:
22
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections
microarray: suitable
western blot: 1:1,000 using recombinant human calretinin
microarray: suitable
western blot: 1:1,000 using recombinant human calretinin
Uniprot accession no.:
产品名称
Anti-Calretinin antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 29 kDa
species reactivity
rat, human, chicken
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections
microarray: suitable
western blot: 1:1,000 using recombinant human calretinin
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CALB2(794)
rat ... Calb2(117059)
Application
Anti-Calretinin antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.
Anti-Calretinin antibody produced in rabbit is suitable for the following applications:
- immunohistochemistry
- microarray
- western blotting at a dilution of 1:1,000 using recombinant human calretinin
Biochem/physiol Actions
The physiological function of calretinin is not known, but it seems to be related to Ca2+ buffering and diffusion. Calretinin-deficient mice show impaired long-term potentiation (LTP) in the dentate gyrus, impaired motor coordination and Purkinje cell excitability. A role for both calretinin and calbindin-D-28K in synaptic plasticity and in neuroprotection from excitotoxic insults has been postulated. By acting as a buffer or sensor of intracellular free Ca2+, calretinin promotes calcium homeostasis. Furthermore, several truncated forms of calretinin have been found in certain tumor cells, but are absent from normal cells, suggesting that calretinin may play a role in tumorigenesis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-Calretinin is developed in rabbit using a synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Calretinin is an intracellular Ca2+-binding protein, with broad tissue distribution and is a member of the calmodulin superfamily. It is expressed in certain populations of neurons in the central and peripheral nervous systems. It is abundant in the cerebellum (granule cells), olfactory bulb and auditory pathways.
Immunogen
synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to KLH. This sequence is specific for calretinin and not found in other members of the EF-hand family such as calbindin-D-28K, calbindin-D-9K, myosin light chain, parvalbumin, S-100a, S-100b, S100A2 (S100L) and S100A6 (calcyclin). This sequence is identical in human and mouse calretinin and highly conserved in chicken calretinin.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin
Schiffmann SN, et al.
Proceedings of the National Academy of Sciences of the USA, 96(9), 5257-5262 (1999)
Calretinin: from a ?simple? Ca2+ buffer to a multifunctional protein implicated in many biological processes
Schwaller B
Frontiers in Neuroanatomy, 8(3), 3-3 (2014)
Inhibition of Glycogen Synthase Kinase 3 beta Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice
Boren J, et al.
The American Journal of Pathology, 187(11), 2461-2472 (2017)
Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla
Szalak R, et al.
Polish Journal of Veterinary Sciences, 18(4), 857-863 (2015)
Shuzi Owens et al.
American journal of physiology. Lung cellular and molecular physiology, 308(12), L1265-L1273 (2015-04-19)
Pleural organization follows acute injury and is characterized by pleural fibrosis, which may involve the visceral and parietal pleural surfaces. This process affects patients with complicated parapneumonic pleural effusions, empyema, and other pleural diseases prone to pleural fibrosis and loculation.
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