产品名称
Caspase 6 human, recombinant, expressed in E. coli, >90% (SDS-PAGE), lyophilized powder, 13,000 units/mg protein
recombinant
expressed in E. coli
assay
>90% (SDS-PAGE)
form
lyophilized powder
specific activity
13,000 units/mg protein
mol wt
~30 kDa
solubility
PBS: soluble
shipped in
dry ice
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
Cleaves the substrates consisting of consensus sequence VEID.
Spontaneously undergoes autoprocessing to yield the subunits associated to form the active enzyme.
Useful in screening caspase inhibitors, studying enzyme regulation, determining specificity of caspase substrates, or as a positive control in caspase activity assays.
Other Notes
One unit will hydrolyze 1 nmol of the caspase substrate VEID-pNA to VEID and p-nitroaniline per hour at pH 7.2 at 37 °C.
Physical form
Contains 0.052% ammonium sulfate, 0.158% Tris−HCl, 0.76% sodium chloride.
法规信息
监管及禁止进口产品
此项目有
Ana A Baburamani et al.
Developmental neuroscience, 37(4-5), 321-337 (2015-04-01)
Apoptotic mechanisms are centre stage for the development of injury in the immature brain, and caspases have been shown to play a pivotal role during brain development and in response to injury. The inhibition of caspases using broad-spectrum agents such
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