C7505
L -胱硫醚
≥98% (TLC), suitable for UHPLC
别名:
( R )-S-（2-氨基-2-羧乙基）- L -同型半胱氨酸
产品名称
L -胱硫醚, ≥98% (TLC)
方案
≥98% (TLC)
表单
powder
技术
UHPLC: suitable
颜色
white
mp
>300 °C
储存温度
−20°C
SMILES字符串
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
InChI
1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
InChI key
ILRYLPWNYFXEMH-WHFBIAKZSA-N
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应用
L-胱硫醚已被用于超高效液相色谱中，用于验证胱硫醚及其丰度与脊椎动物变态的相关性。 它还被用作窦状GSH（谷胱甘肽）载体的抑制剂，以表明巯基氧化还原状态失衡与癌细胞中自噬的调节有关。
生化/生理作用
L-胱硫醚是 L-半胱氨酸和蛋氨酸生物合成的中间体。 作为底物用于分化分析胱硫醚 γ-裂解酶。L-胱硫醚是一种重要的非蛋白氨基酸，与代谢紊乱有关。在最近的研究中，L-胱硫醚被认为是环亚氨基环硫氨酸的前体。胱硫醚尿症的特征是尿中排出亚氨基酸环硫氨酸。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization.
Nagasawa T
The Journal of Biological Chemistry, 259(16), 10393-10403 (1984)
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
Ricci G
European Journal of Biochemistry, 157(1), 57-63 (1986)
Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis.
Amino Y
Bioscience, Biotechnology, and Biochemistry, 81(1), 95-101 (2017)
Jennifer Kim et al.
FEMS microbiology letters, 328(2), 114-121 (2012-01-04)
Streptococcus mutans, a primary dental pathogen, has a remarkable capacity to scavenge nutrients from the oral biofilm for its survival. Cystine is an amino acid dimer formed by the oxidation of two cysteine residues that is required for optimal growth
G Ricci et al.
The Journal of biological chemistry, 258(17), 10511-10517 (1983-09-10)
L-Cystathionine is oxidized by snake venom L-amino acid oxidase at a rate about half that with L-leucine at pH 8.5. The appearance of an absorbance at 296 nm and quantitation of the products of oxidation in the presence of catalase
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