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C7505

L -胱硫醚

Name: <SC>L </SC>-胱硫醚
Brand: SIGMA

≥98% (TLC), suitable for UHPLC

别名:

( R )-S-（2-氨基-2-羧乙基）- L -同型半胱氨酸

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关于此项目

经验公式（希尔记法）:

C₇H₁₄N₂O₄S

化学文摘社编号:

56-88-2

分子量:

222.26

NACRES:

NA.26

PubChem Substance ID:

24892965

UNSPSC Code:

12352209

EC Number:

200-295-8

MDL number:

MFCD00036685

Beilstein/REAXYS Number:

2505200

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产品名称

L -胱硫醚, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

technique(s)

UHPLC: suitable

color

white

mp

>300 °C

storage temp.

−20°C

SMILES string

N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1

InChI key

ILRYLPWNYFXEMH-WHFBIAKZSA-N

Application

L-胱硫醚已被用于超高效液相色谱中，用于验证胱硫醚及其丰度与脊椎动物变态的相关性。它还被用作窦状GSH（谷胱甘肽）载体的抑制剂，以表明巯基氧化还原状态失衡与癌细胞中自噬的调节有关。

Biochem/physiol Actions

L-胱硫醚是 L-半胱氨酸和蛋氨酸生物合成的中间体。作为底物用于分化分析胱硫醚 γ-裂解酶。L-胱硫醚是一种重要的非蛋白氨基酸，与代谢紊乱有关。在最近的研究中，L-胱硫醚被认为是环亚氨基环硫氨酸的前体。胱硫醚尿症的特征是尿中排出亚氨基酸环硫氨酸。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.

Ricci G

European Journal of Biochemistry, 157(1), 57-63 (1986)

Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis.

Amino Y

Bioscience, Biotechnology, and Biochemistry, 81(1), 95-101 (2017)

Differential response of methionine metabolism in two grain legumes, soybean and azuki bean, expressing a mutated form of Arabidopsis cystathionine γ-synthase.

Moemen S Hanafy et al.

Journal of plant physiology, 170(3), 338-345 (2013-01-05)

Methionine (Met) is a sulfur-containing amino acid that is essential in mammals and whose low abundance limits the nutritional value of grain legumes. Cystathionine γ-synthase (CGS) catalyzes the first committed step of Met biosynthesis, and the stability of its mRNA

Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies.

Amany K Elshorbagy et al.

Current opinion in clinical nutrition and metabolic care, 15(1), 49-57 (2011-11-24)

The concentrations of several plasma amino acids increase in obesity. Notably, plasma total concentrations of the sulphur amino acid cysteine (tCys) are linearly associated with fat mass in large population studies. Animal and cellular experiments support the concept that cysteine

Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization.

Nagasawa T

The Journal of Biological Chemistry, 259(16), 10393-10403 (1984)

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全球贸易项目编号

货号	GTIN
C7505-50MG	04061832415970
C7505-10MG	04061832415956
C7505-250MG	04061832415963

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