C7505
L -胱硫醚
≥98% (TLC), suitable for UHPLC
别名:
( R )-S-（2-氨基-2-羧乙基）- L -同型半胱氨酸
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关于此项目
经验公式（希尔记法）:
C7H14N2O4S
化学文摘社编号:
分子量:
222.26
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-295-8
MDL number:
Beilstein/REAXYS Number:
2505200
产品名称
L -胱硫醚, ≥98% (TLC)
InChI key
ILRYLPWNYFXEMH-WHFBIAKZSA-N
InChI
1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
SMILES string
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
assay
≥98% (TLC)
form
powder
technique(s)
UHPLC: suitable
color
white
mp
>300 °C
storage temp.
−20°C
Quality Level
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Application
L-胱硫醚已被用于超高效液相色谱中，用于验证胱硫醚及其丰度与脊椎动物变态的相关性。 它还被用作窦状GSH（谷胱甘肽）载体的抑制剂，以表明巯基氧化还原状态失衡与癌细胞中自噬的调节有关。
Biochem/physiol Actions
L-胱硫醚是 L-半胱氨酸和蛋氨酸生物合成的中间体。 作为底物用于分化分析胱硫醚 γ-裂解酶。L-胱硫醚是一种重要的非蛋白氨基酸，与代谢紊乱有关。在最近的研究中，L-胱硫醚被认为是环亚氨基环硫氨酸的前体。胱硫醚尿症的特征是尿中排出亚氨基酸环硫氨酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
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Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis.
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Bioscience, Biotechnology, and Biochemistry, 81(1), 95-101 (2017)
Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies.
Amany K Elshorbagy et al.
Current opinion in clinical nutrition and metabolic care, 15(1), 49-57 (2011-11-24)
The concentrations of several plasma amino acids increase in obesity. Notably, plasma total concentrations of the sulphur amino acid cysteine (tCys) are linearly associated with fat mass in large population studies. Animal and cellular experiments support the concept that cysteine
Moemen S Hanafy et al.
Journal of plant physiology, 170(3), 338-345 (2013-01-05)
Methionine (Met) is a sulfur-containing amino acid that is essential in mammals and whose low abundance limits the nutritional value of grain legumes. Cystathionine γ-synthase (CGS) catalyzes the first committed step of Met biosynthesis, and the stability of its mRNA
G Ricci et al.
The Journal of biological chemistry, 258(17), 10511-10517 (1983-09-10)
L-Cystathionine is oxidized by snake venom L-amino acid oxidase at a rate about half that with L-leucine at pH 8.5. The appearance of an absorbance at 296 nm and quantitation of the products of oxidation in the presence of catalase
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