C7604
抗-γ-微管蛋白
affinity isolated antibody, buffered aqueous solution
别名:
Anti-γ-Tubulin
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
CY3 conjugate
Clone:
polyclonal
Application:
IF (d)
Citations:
11
biological source
rabbit
conjugate
CY3 conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
human, chicken
technique(s)
direct immunofluorescence: 1:200 using methanol/acetone-fixed chicken fibroblats cells or HeLa cells (human).
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... TUBG1(7283), TUBG2(27175)
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General description
γ-Tubulin (48 kDa) is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.
Tubulin, γ 1 is a protein encoded by the TUBG1 gene in humans. This gene encodes a member of the tubulin superfamily. γ-tubulin interacts with Arp2/3, a complex that nucleates actin filaments and with the Arp2/3 activator WASH. It is found to have relationship with actin filament dynamics.
Immunogen
对应人 γ-微管蛋白（氨基酸 38-53，C 端添加赖氨酸） N 端区域的合成肽与 KLH 结合。该序列对 γ-微管蛋白具有特异性，而对微管蛋白家族的其他成员如 α−β−, δ和 ε−微管蛋白。该序列在小鼠和大鼠的 γ-微管蛋白中相同，并在物种（ 果蝇 、 曲霉 和酵母 γ-微管蛋白）中高度保留。
Application
Anti-γ- Tubulin-Cy3 antibody produced in rabbit has been used in direct immunofluorescence (IF)and immunofluorescent staining.
Anti-γ-Tubulin-Cy3™ antibody produced in rabbit is suitable for direct immunofluorescence at a dilution of 1:200 using methanol/acetone-fixed chicken fibroblats cells or HeLa cells (human).
Biochem/physiol Actions
γ-Tubulin binds the microtubule minus ends and is responsible for mediating the link between microtubules and the centrosome.
γ-Tubulins in the γ-TuRC might promote microtubule nucleation by providing a template that enhances the intrinsically weak lateral interaction between αβ-tubulin heterodimers when associated laterally. It has a unique functional property of a monomeric tubulin. γ-tubulin is also found to be expressed in lung cancer. Cep70 as an important centrosomal protein that interacts with γ-tubulin and plays a critical role in the regulation of mitotic spindle assembly.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Legal Information
Cy is distributed under license from Amersham Biosciences Limited.
Cy3 is a trademark of Cytiva
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Thermosensitive microgels of poly-N-isopropylacrylamide for drug carriers?Practical approach to synthesis
Musial W, et al.
Acta Poloniae Pharmaceutica, 72, 409-422 (2015)
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
Grzelak CA, et al.
Testing, 12(2), e0171480-e0171480 (2017)
Hector Aldaz et al.
Nature, 435(7041), 523-527 (2005-05-27)
Microtubules are hollow polymers of alphabeta-tubulin that show GTP-dependent assembly dynamics and comprise a critical part of the eukaryotic cytoskeleton. Initiation of new microtubules in vivo requires gamma-tubulin, organized as an oligomer within the 2.2-MDa gamma-tubulin ring complex (gamma-TuRC) of
Xingjuan Shi et al.
The Journal of biological chemistry, 286(38), 33401-33408 (2011-07-29)
Deregulation of the mitotic spindle has been implicated in genomic instability, an important aspect of tumorigenesis and malignant transformation. To ensure the fidelity of chromosome transmission, the mitotic spindle is assembled by exquisite mechanisms and orchestrated by centrosomes in animal
Candice Alexandra Grzelak et al.
PloS one, 12(2), e0171480-e0171480 (2017-02-12)
Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, GLI activation can occur independently of the canonical Hh pathway. Using a murine model of liver injury
商品
Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.
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