抗-γ-微管蛋白

γ-Tubulin (48 kDa) is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.

Tubulin, γ 1 is a protein encoded by the TUBG1 gene in humans. This gene encodes a member of the tubulin superfamily. γ-tubulin interacts with Arp2/3, a complex that nucleates actin filaments and with the Arp2/3 activator WASH. It is found to have relationship with actin filament dynamics.

对应人 γ-微管蛋白（氨基酸 38-53，C 端添加赖氨酸） N 端区域的合成肽与 KLH 结合。该序列对 γ-微管蛋白具有特异性，而对微管蛋白家族的其他成员如 α−β−, δ和 ε−微管蛋白。该序列在小鼠和大鼠的 γ-微管蛋白中相同，并在物种（ 果蝇 、 曲霉 和酵母 γ-微管蛋白）中高度保留。

Anti-γ- Tubulin-Cy3 antibody produced in rabbit has been used in direct immunofluorescence (IF)and immunofluorescent staining.

Anti-γ-Tubulin-Cy3^™ antibody produced in rabbit is suitable for direct immunofluorescence at a dilution of 1:200 using methanol/acetone-fixed chicken fibroblats cells or HeLa cells (human).

γ-Tubulin binds the microtubule minus ends and is responsible for mediating the link between microtubules and the centrosome.

γ-Tubulins in the γ-TuRC might promote microtubule nucleation by providing a template that enhances the intrinsically weak lateral interaction between αβ-tubulin heterodimers when associated laterally. It has a unique functional property of a monomeric tubulin. γ-tubulin is also found to be expressed in lung cancer. Cep70 as an important centrosomal protein that interacts with γ-tubulin and plays a critical role in the regulation of mitotic spindle assembly.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

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