C7744
溴他汀 A4
≥98% (HPLC), vascular disrupting agent, powder
别名:
1-（3,4,5-三甲氧基苯基）-2-（3′-羟基-4′-甲氧基苯基）乙烷 3,4,5-三甲氧基-3′-羟基-4′--甲氧基芪, 2-甲氧基-5-[(1Z)-2-（3,4,5-三甲氧基苯基）乙烯基] 苯酚, CA4
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关于此项目
经验公式（希尔记法）:
C18H20O5
化学文摘社编号:
分子量:
316.35
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
溴他汀 A4, ≥98% (HPLC), powder
SMILES string
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
InChI key
HVXBOLULGPECHP-WAYWQWQTSA-N
InChI
1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Quality Level
Application
考布他汀A4已被用于：
- 作为抗微管剂用于确定G2/M期异柠檬酸脱氢酶（IDH1和IDH2）蛋白的作用
- 评估联苯CA4衍生物在2D和3D癌细胞和非癌细胞模型中的的抗增生和促凋亡特性
- 作为微管抑制剂用于研究其对猪蛔虫L3幼虫的作用
Biochem/physiol Actions
Combretastatin A4是一种靶向肿瘤血管以抑制血管生成的血管分裂剂(VDA)。
Combretastatin A4是一种靶向肿瘤血管以抑制血管生成的血管分裂剂(VDA)。它在β-微管蛋白的秋水仙碱结合位点抑制微管蛋白聚合。它通过抑制人胃细胞中的AKT功能而具有抗肿瘤活性。被抑制的 AKT 激活引起细胞增殖下降，细胞周期停滞，在体外 迁移/侵袭和 体内 转移能力降低 。Combretastatin A4 是一种天然二苯乙烯类苯酚。
考布他汀A4是一种强效的微管靶向剂。
General description
考布他汀A4属于秋水仙碱类。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Christian Damsgaard et al.
eLife, 9 (2020-08-26)
Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et
Medicinal chemistry of combretastatin A4: present and future directions.
Gian Cesare Tron et al.
Journal of medicinal chemistry, 49(11), 3033-3044 (2006-05-26)
Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells
Bala Bhaskara Rao K, et al.
Febs Letters, 593(16), 2177-2193 (2019)
De novo identification of toxicants that cause irreparable damage to parasitic nematode intestinal cells
Jasmer DP, et al.
PLoS Neglected Tropical Diseases, 14(5), e0007942-e0007942 (2020)
B Cao et al.
Molecular psychiatry, 22(9), 1352-1358 (2017-01-25)
Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including
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