C7744
溴他汀 A4
≥98% (HPLC), powder
别名:
1-（3,4,5-三甲氧基苯基）-2-（3′-羟基-4′-甲氧基苯基）乙烷 3,4,5-三甲氧基-3′-羟基-4′--甲氧基芪, 2-甲氧基-5-[(1Z)-2-（3,4,5-三甲氧基苯基）乙烯基] 苯酚, CA4
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关于此项目
经验公式（希尔记法）:
C18H20O5
CAS Number:
分子量:
316.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
InChI
1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChI key
HVXBOLULGPECHP-WAYWQWQTSA-N
一般描述
考布他汀A4属于秋水仙碱类。
应用
考布他汀A4已被用于：
- 作为抗微管剂用于确定G2/M期异柠檬酸脱氢酶（IDH1和IDH2）蛋白的作用
- 评估联苯CA4衍生物在2D和3D癌细胞和非癌细胞模型中的的抗增生和促凋亡特性
- 作为微管抑制剂用于研究其对猪蛔虫L3幼虫的作用
生化/生理作用
Combretastatin A4是一种靶向肿瘤血管以抑制血管生成的血管分裂剂(VDA)。
Combretastatin A4是一种靶向肿瘤血管以抑制血管生成的血管分裂剂(VDA)。它在β-微管蛋白的秋水仙碱结合位点抑制微管蛋白聚合。它通过抑制人胃细胞中的AKT功能而具有抗肿瘤活性。被抑制的 AKT 激活引起细胞增殖下降，细胞周期停滞，在体外 迁移/侵袭和 体内 转移能力降低 。Combretastatin A4 是一种天然二苯乙烯类苯酚。
考布他汀A4是一种强效的微管靶向剂。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christian Damsgaard et al.
eLife, 9 (2020-08-26)
Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et
Dietmar W Siemann et al.
Expert opinion on investigational drugs, 18(2), 189-197 (2009-02-25)
Vascular-disrupting strategies impair a tumor's blood vessel network, which is essential for tumor progression and metastasis. Vascular-disrupting agents (VDAs) cause a rapid and selective vascular shutdown in tumors to produce extensive secondary neoplastic cell death due to ischemia. A lead
De novo identification of toxicants that cause irreparable damage to parasitic nematode intestinal cells
Jasmer DP, et al.
PLoS Neglected Tropical Diseases, 14(5), e0007942-e0007942 (2020)
B Cao et al.
Molecular psychiatry, 22(9), 1352-1358 (2017-01-25)
Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1-4, the dentate gyrus (DG) including
S Papiol et al.
Translational psychiatry, 7(6), e1159-e1159 (2017-06-28)
Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume changes are unknown but might be connected to the load of risk genes. Genome-wide association
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