biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50 kDa
species reactivity
human, rat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using rat spleen, microarray: suitable, western blot: 1:2,000 using a whole cell extract of human Jurkat cell line and a cytosolic fraction of embryonic rat brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CSK(1445)
mouse ... Csk(12988)
rat ... Csk(315707)
General description
Csk is a widely expressed non-receptor tyrosine kinase that consists of a catalytic domain, as well as SH2 and SH3 domains. This kinase phosphorylates the C-terminal tail of Src-family protein tyrosine kinases (SFKs) and subsequently inhibits SFKs. As SFKs have been associated carcinogenesis, Csk may have implications in cancer therapeutics
Anti-Csk antibody is specific for human and rat Csk. The product may also react with mouse Csk. In immunoblotting, staining of Csk is specifically inhibited with the Csk immunizing peptide (rat, amino acids 433-450).
Anti-Csk antibody is specific for human and rat Csk. The product may also react with mouse Csk. In immunoblotting, staining of Csk is specifically inhibited with the Csk immunizing peptide (rat, amino acids 433-450).
Immunogen
peptide corresponding to amino acids 433-450 at the C-terminus of rat Csk. This sequence is highly conserved in human and mouse.
Application
Anti-Csk antibody is suitable for use in western blot (1:2,000 using whole cell extracts of human Jurkat cell line and cytosolic fractions of embryonic rat brain). The product may also be used for microarray and immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections of rat spleen).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.