产品名称
辅酶Q1, ≥95%
InChI
1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3
SMILES string
COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O
InChI key
SOECUQMRSRVZQQ-UHFFFAOYSA-N
assay
≥95%
form
liquid
storage temp.
−20°C
Quality Level
Application
辅酶Q1已用于检测线粒体呼吸链复合物1的活性。
Biochem/physiol Actions
辅酶Q1(CoQ1)是泛醌家族的1异戊烯基成员(非天然),这些泛醌均有一个奎宁化学基团,但尾部异戊烯基化学亚基的数量不同。 辅酶Q类化合物是细胞膜的脂溶性组分,可以行使多种功能,例如电子和质子传递。 研究最充分的辅酶Q类化合物是辅酶Q10(CoQ10)。 CoQ1常在比较研究中用于探索不同异戊烯链长对CoQ功能或分布的影响,还可用于醌还原酶的鉴定。
General description
辅酶Q(CoQ)位于线粒体磷脂双层膜、血浆脂蛋白和其他生物膜的疏水区域。是带有短的类萜侧链的泛醌同系物。
Other Notes
辅酶 Q10 的类似物(非天然存在)
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for
Keisuke Hikosaka et al.
Colloids and surfaces. B, Biointerfaces, 66(2), 195-200 (2008-07-26)
This study was designed to examine if platinum nanoparticles have an activity similar to mitochondrial complex I, NADH:ubiquinone oxidoreductase. Platinum nanoparticles were prepared by a citrate reduction of H(2)PtCl(6) and protected by citrate itself and pectin (CP-Pt). Time- and dose-dependent
R Laaksonen et al.
Clinical pharmacology and therapeutics, 57(1), 62-66 (1995-01-01)
Statins, which are commonly used drugs for hypercholesterolemia, inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. Important nonsterol compounds, such as ubiquinone, are also derived from the same synthetic pathway. Therefore it has been hypothesized that statin
Chang Sun et al.
Nature, 557(7703), 123-126 (2018-04-27)
Alternative complex III (ACIII) is a key component of the respiratory and/or photosynthetic electron transport chains of many bacteria1-3. Like complex III (also known as the bc1 complex), ACIII catalyses the oxidation of membrane-bound quinol and the reduction of cytochrome
Kathrin Fenn et al.
Microbiome, 5(1), 161-161 (2017-12-22)
The human gut microbiome has been linked to numerous components of health and disease. However, approximately 25% of the bacterial species in the gut remain uncultured, which limits our ability to properly understand, and exploit, the human microbiome. Previously, we
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