C7956
辅酶Q1
≥95%
别名:
2,3-二甲氧基-5-甲基-6-（3-甲基-2-丁烯基）-1,4-苯醌, 泛醌-1, 泛醌-5
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关于此项目
经验公式（希尔记法）:
C14H18O4
化学文摘社编号:
分子量:
250.29
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
产品名称
辅酶Q1, ≥95%
InChI
1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3
SMILES string
COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O
InChI key
SOECUQMRSRVZQQ-UHFFFAOYSA-N
assay
≥95%
form
liquid
storage temp.
−20°C
Quality Level
Application
辅酶Q1已用于检测线粒体呼吸链复合物1的活性。
Biochem/physiol Actions
辅酶Q1(CoQ1)是泛醌家族的1异戊烯基成员（非天然），这些泛醌均有一个奎宁化学基团，但尾部异戊烯基化学亚基的数量不同。 辅酶Q类化合物是细胞膜的脂溶性组分，可以行使多种功能，例如电子和质子传递。 研究最充分的辅酶Q类化合物是辅酶Q10(CoQ10)。 CoQ1常在比较研究中用于探索不同异戊烯链长对CoQ功能或分布的影响，还可用于醌还原酶的鉴定。
General description
辅酶Q(CoQ)位于线粒体磷脂双层膜、血浆脂蛋白和其他生物膜的疏水区域。是带有短的类萜侧链的泛醌同系物。
Other Notes
辅酶 Q10 的类似物（非天然存在）
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Alfonso Varela-López et al.
Molecules (Basel, Switzerland), 21(3), 373-373 (2016-03-22)
Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is
Coenzyme Q cytoprotective mechanisms.
Tom S Chan et al.
Methods in enzymology, 382, 89-104 (2004-03-30)
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for
Giancarlo A Biagini et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8298-8303 (2012-05-09)
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure
P G Elmberger et al.
Lipids, 24(11), 919-930 (1989-11-01)
An effective system for perfusing rat liver using complete tissue culture medium and washed calf erythrocytes as oxygen carriers was devised. Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period.
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