C7971
环己喹酰胺
≥97% (HPLC), PDE3 inhibitor, powder
别名:
6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
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关于此项目
经验公式（希尔记法）:
C20H26N2O3
化学文摘社编号:
分子量:
342.43
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
产品名称
环己喹酰胺, phosphodiesterase inhibitor
质量水平
方案
≥97% (HPLC)
表单
powder
溶解性
DMSO: 20 mg/mL, clear, colorless to faintly yellow
SMILES字符串
CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
InChI
1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key
UIAYVIIHMORPSJ-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)
相关类别
生化/生理作用
PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.
Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC50 = 70 ± 9 nM.
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Byung Chul Jee et al.
Fertility and sterility, 91(5 Suppl), 2037-2042 (2008-06-17)
To investigate the effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent embryo development. Animal study. University laboratory. CD-1 mice. Immature oocytes were arrested meiotically in medium containing a specific phosphodiesterase type 3 inhibitor, cilostamide (1
Targeting tumor cells based on Phosphodiesterase 3A expression
Nazir M, et al.
Experimental Cell Research, 361(2), 308-315 (2017)
Xiaofei Zhu et al.
BMC urology, 17(1), 54-54 (2017-07-09)
It has been shown that hosphodiesterases (PDEs) play an important role in mediating the smooth muscle tone of rat urinary bladder. However, the gene expression profiles of them were still unknown. Urinary bladder Strips were obtained from both neonatal and
Effects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytes
Shu Y, et al.
Human Reproduction, 23(3), 504-513 (2008)
F K Albuz et al.
Human reproduction (Oxford, England), 25(12), 2999-3011 (2010-09-28)
Oocyte in vitro maturation (IVM) reduces the need for gonadotrophin-induced ovarian hyperstimulation and its associated health risks but the unacceptably low conception/pregnancy rates have limited its clinical uptake. We report the development of a novel in vitro simulated physiological oocyte
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