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About This Item
经验公式（希尔记法）:
C20H26N2O3
CAS Number:
分子量:
342.43
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥97% (HPLC)
表单
powder
溶解性
DMSO: 20 mg/mL, clear, colorless to faintly yellow
SMILES字符串
CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
InChI
1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key
UIAYVIIHMORPSJ-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)
相关类别
生化/生理作用
PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.
Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC50 = 70 ± 9 nM.
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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