产品名称
抗皮质醇 兔抗, whole antiserum, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
technique(s)
radioimmunoassay: suitable (dextran coated charcoal 3H RIA)
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
相关类别
Application
抗皮质醇抗体可用于血浆激素测定和免疫荧光实验。
抗皮质醇抗体适用于RIA。可用于ELISA法检测鱼类血液中的皮质醇水平。该抗体还用于鳟鱼鳃丝切片的免疫组化实验,工作稀释度为1:5。
Biochem/physiol Actions
皮质醇是人体肾上腺皮质分泌的最主要的糖皮质激素。以可的松的形式产生,但由酶11β-羟基类固醇脱氢酶(11-HSD)催化转化为生物活性形式:皮质醇。皮质醇与血浆中的皮质类固醇结合球蛋白结合。产生11-HSD并参与代谢和清除血浆皮质醇的器官是肾脏和肝脏。皮质醇可在11羟基位被氧化,产生可的松、二氢可的松或四氢可的松。皮质醇和其他糖皮质激素与主要存在于细胞质中的人类糖皮质激素受体(hGR)结合。结合后,受体-配体络合物转移到细胞核,继而在细胞核中诱导靶基因转录。 11-HSD 水平缺乏可导致青少年高血压(表象性盐皮质激素过多综合征的症状)、水肿、心力衰竭和低钾血症(甘草中毒)。
Disclaimer
除非我们的目录或随附于产品的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
皮质醇是人体肾上腺皮质的主要分泌糖皮质激素。以可的松的形式产生,但通过酶 11β-羟化类固醇脱氢酶(11-HSD)的活性转化为生物活性形式:皮质醇。
Immunogen
皮质醇-21-甲状腺球蛋白。
Preparation Note
用 5 mL 缓冲液重建:0.05 MTris-HCl(pH 8.0)、0.1 M 氯化钠、0.1% 明胶和 15 mM 叠氮化钠。将该储备液储存于−20°C。未在12小时内使用的工作稀释液(1:10)应丢弃。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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