C8739
Cyclin-Dependent Kinase 5 human
recombinant, expressed in E. coli BL21, 50-100 units/μg protein
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关于此项目
Specific activity:
50-100 units/μg protein
Recombinant:
expressed in E. coli BL21
产品名称
Cyclin-Dependent Kinase 5 human, recombinant, expressed in E. coli BL21, 50-100 units/μg protein
recombinant
expressed in E. coli BL21
form
solution
specific activity
50-100 units/μg protein
packaging
vial of 300 units
shipped in
dry ice
storage temp.
−70°C
Quality Level
Application
Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.
Biochem/physiol Actions
CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.
Other Notes
One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4.
Physical form
Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Pharmacological inhibitors of cyclin-dependent kinases
Knockaert M, et al.
Trends in Pharmacological Sciences, 23(9), 417-425 (200)
Kwok-On Lai et al.
The Journal of biological chemistry, 290(23), 14637-14646 (2015-04-24)
The maturation and maintenance of dendritic spines depends on neuronal activity and protein synthesis. One potential mechanism involves mammalian target of rapamycin, which promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70 ribosomal S6 kinase 1 (S6K). Upon extracellular
Silvia Moncini et al.
BMC molecular biology, 8, 111-111 (2007-12-07)
CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development. CDK5R1 has been implicated in neurodegenerative disorders and proposed as a candidate gene for mental retardation. The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests
Shu Zhang et al.
PloS one, 10(7), e0131833-e0131833 (2015-07-07)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell
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