C8791
Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse
clone CKB1, ascites fluid
别名:
Anti-CK14, Anti-EBS1, Anti-EBS1A, Anti-EBS1B, Anti-EBS1C, Anti-EBS1D, Anti-EBS3, Anti-EBS4, Anti-K14, Anti-NFJ
产品名称
Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse, clone CKB1, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
CKB1, monoclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:200 using methacarn-fixed, paraffin-embedded human tissue sections
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT14(3861)
Application
Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse has been used in indirect immunofluorescence or immunoperoxidase techniques.
Biochem/physiol Actions
Keratin 14 (KRT14) is associated with maintaining cellular stability. Mutation in the KRT14 gene leads to epidermolysis bullosa simplex, a genetic disorder. It is known to promote angiogenesis, cell migration and proliferation in cancer cells.
The antibody reacts with myoepithelial cells in various organs (parotid, submandibular, mammary, prostate, and sweat glands) as well as with the basal layer of certain squamous epithelium (exocervical, laryngeal epithelium).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Cytokeratin Peptide 14 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Keratin 14 (KRT14) is expressed in keratinocytes and localized to the basal epidermal layer. The gene is mapped to human chromosome 17q21 and encodes an intermediate filament.
Immunogen
human callus keratins.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Amina Errazahi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 18(4), 737-750 (2003-04-04)
The presence of identical or distinct type I parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptors in keratinocytes is still a matter of debate. We studied the expression and functionality of PTHrP receptors in freshly isolated keratinocytes from newborn rat skin.
Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases
Kocher, et al.
Molecular Therapy, 25(11), 2585-2585 (2017)
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-alpha expression levels
Zheng Y, et al.
Oncotarget, 7(38), 62159-62159 (2016)
Maja Matic et al.
Methods in molecular biology (Clifton, N.J.), 289, 193-200 (2004-10-27)
Single-cell suspensions of primary keratinocytes comprise a heterogeneous cell population that consists of basal cells (stem cells, transient amplifying cells, and post-mitotic basal cells) and suprabasal cells at different stages of differentiation. Quantitative data for the differential expression of epitopes
Severe asthma: Differential chemokine response of airway epithelial cells.
Biju Thomas et al.
The Journal of allergy and clinical immunology, 140(4), 1149-1152 (2017-04-17)
相关内容
Datasheet
Datasheet
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