产品名称
Anti-Cyclin B1 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 62 kDa
species reactivity
human, mouse, hamster
technique(s)
indirect immunofluorescence: 1:30
microarray: suitable
western blot: 1:100
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CCNB1(891)
mouse ... Ccnb1(268697)
Application
Anti-cyclin B1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1) complex play a crucial role in regulation of mitosis. Elevated expression of the gene has been observed in various types of human cancers including breast, lung, colon, prostate and head and neck cancers. Thus, this protein can be considered as a potent target for cancer vaccines. In addition, CCNB1 also serves as a prognostic biomarker for estrogen-receptor-positive (ER+) breast cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The cyclin B1 (CCNB1) gene is mapped to human chromosome 5q13.2. The gene codes for a 62kDa protein containing a classical cyclin box domain. CCNB1 shuttles between the nucleus and cytoplasm until prophase begins. It is a member of the cyclin family and is expressed at low levels in normal cells.
Immunogen
recombinant hamster cyclin B1
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
CCNB1 is a prognostic biomarker for ER+ breast cancer
Ding K, et al.
Medical Hypotheses, 83, 359-364 (2014)
Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer
Fang Y, et al.
Cancer Biology & Therapy, 15, 1268-1279 (2014)
Bárbara Pinto et al.
Pharmaceutics, 16(1) (2024-01-23)
Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule-targeting antimitotic agents (e.g., paclitaxel) to circumvent resistance and side effects associated with their use. They can be classified
Importance of tuberin in carcinogenesis.
Jin M, et al.
Oncology Letters, 14, 2598-2602 (2017)
Virus infection disturbs cyclin expression, leading to cell cycle arrest in the unicellular marine algae Emiliania huxleyi and Chrysochromulina ericina
Liu J, et al.
African Journal of Microbiology Research, 5, 1801-1807 (2011)
相关内容
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